Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 187833..188371 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag EEL44_RS01185 Protein ID WP_000802136.1
Coordinates 188072..188371 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag EEL44_RS01180 Protein ID WP_001107719.1
Coordinates 187833..188075 (+) Length 81 a.a.

Genomic Context

EEL44_RS01180EEL44_RS01185EEL44_RS01125EEL44_RS01130EEL44_RS01135EEL44_RS01145EEL44_RS01155EEL44_RS01165EEL44_RS01170EEL44_RS01190EEL44_RS01195EEL44_RS01210EEL44_RS01215EEL44_RS01220EEL44_RS01225EEL44_RS01230EEL44_RS01235
Location: 187833..188075 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
Location: 188072..188371 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 183249..183389 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 183355..184290 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 184571..185170 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 185325..185591 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 185805..186488 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 186912..187004 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 187026..187604 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 188499..188894 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 189108..189287 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 189865..189975 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 189985..190683 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 190806..191432 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 191474..191566 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 191581..192054 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 192254..192436 (183 bp)
Type: Others
Protein ID: WP_000923182.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EEL44_RS01125183249..183389-141WP_001883049.1DUF3265 domain-containing protein-
EEL44_RS01130183355..184290-936WP_000051985.1restriction endonuclease-
EEL44_RS01135184571..185170-600WP_000429495.1hypothetical protein-
EEL44_RS01145185325..185591-267WP_000937852.1hypothetical protein-
EEL44_RS01155185805..186488-684WP_000877436.1hypothetical protein-
EEL44_RS01165186912..187004-93WP_014164112.1DUF3265 domain-containing protein-
EEL44_RS01170187026..187604-579WP_000110120.1hypothetical protein-
EEL44_RS01180187833..188075+243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
EEL44_RS01185188072..188371+300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EEL44_RS01190188499..188894-396WP_000870857.1DUF3465 domain-containing protein-
EEL44_RS01195189108..189287-180WP_001883058.1DUF645 family protein-
EEL44_RS01210189865..189975-111WP_079857360.1DUF3265 domain-containing protein-
EEL44_RS01215189985..190683-699WP_001890502.1hypothetical protein-
EEL44_RS01220190806..191432-627WP_000365424.1LysE family translocator-
EEL44_RS01225191474..191566-93WP_014378730.1DUF3265 domain-containing protein-
EEL44_RS01230191581..192054-474WP_001161076.1GrpB family protein-
EEL44_RS01235192254..192436-183WP_000923182.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-126763..233717106954
insideIntegron--127139..22687599736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T113806 WP_000802136.1 NZ_CP033513:188072-188371 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T113806 NZ_CP033513:188072-188371 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT113806 WP_001107719.1 NZ_CP033513:187833-188075 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT113806 NZ_CP033513:187833-188075 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References