113806

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 187833..188371 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag EEL44_RS01185 Protein ID WP_000802136.1
Coordinates 188072..188371 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag EEL44_RS01180 Protein ID WP_001107719.1
Coordinates 187833..188075 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS01125 183249..183389 - 141 WP_001883049.1 DUF3265 domain-containing protein -
EEL44_RS01130 183355..184290 - 936 WP_000051985.1 restriction endonuclease -
EEL44_RS01135 184571..185170 - 600 WP_000429495.1 hypothetical protein -
EEL44_RS01145 185325..185591 - 267 WP_000937852.1 hypothetical protein -
EEL44_RS01155 185805..186488 - 684 WP_000877436.1 hypothetical protein -
EEL44_RS01165 186912..187004 - 93 WP_014164112.1 DUF3265 domain-containing protein -
EEL44_RS01170 187026..187604 - 579 WP_000110120.1 hypothetical protein -
EEL44_RS01180 187833..188075 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
EEL44_RS01185 188072..188371 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EEL44_RS01190 188499..188894 - 396 WP_000870857.1 DUF3465 domain-containing protein -
EEL44_RS01195 189108..189287 - 180 WP_001883058.1 DUF645 family protein -
EEL44_RS01210 189865..189975 - 111 WP_079857360.1 DUF3265 domain-containing protein -
EEL44_RS01215 189985..190683 - 699 WP_001890502.1 hypothetical protein -
EEL44_RS01220 190806..191432 - 627 WP_000365424.1 LysE family translocator -
EEL44_RS01225 191474..191566 - 93 WP_014378730.1 DUF3265 domain-containing protein -
EEL44_RS01230 191581..192054 - 474 WP_001161076.1 GrpB family protein -
EEL44_RS01235 192254..192436 - 183 WP_000923182.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 126763..233717 106954
inside Integron - - 127139..226875 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T113806 WP_000802136.1 NZ_CP033513:188072-188371 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T113806 NZ_CP033513:188072-188371 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT113806 WP_001107719.1 NZ_CP033513:187833-188075 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT113806 NZ_CP033513:187833-188075 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References