Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 334939..335437 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag GTF74_RS15295 Protein ID WP_000589156.1
Coordinates 334939..335205 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag GTF74_RS15300 Protein ID WP_000643598.1
Coordinates 335192..335437 (+) Length 82 a.a.

Genomic Context

GTF74_RS15240GTF74_RS15245GTF74_RS15250GTF74_RS15255GTF74_RS15260GTF74_RS15265GTF74_RS15270GTF74_RS15275GTF74_RS15280GTF74_RS15285GTF74_RS15290GTF74_RS15295GTF74_RS15300GTF74_RS15305GTF74_RS15310GTF74_RS15315GTF74_RS15320GTF74_RS15325GTF74_RS15330GTF74_RS15335GTF74_RS15340
Location: 330360..330566 (207 bp)
Type: Others
Protein ID: Protein_294
Location: 330766..330867 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 330857..331243 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 331438..331689 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 331662..331811 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 331903..332145 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 332397..332675 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 333050..333193 (144 bp)
Type: Others
Protein ID: Protein_301
Location: 333247..333285 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 333497..333964 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 334092..334754 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 334939..335205 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 335192..335437 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 335533..336327 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 336430..336558 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 336619..336801 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 337017..338021 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 338174..338533 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 338806..339039 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 339307..339813 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 339970..340356 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF74_RS15240330360..330566+207Protein_294DUF3709 domain-containing protein-
GTF74_RS15245330766..330867+102WP_001921603.1hypothetical protein-
GTF74_RS15250330857..331243+387WP_000703163.1VOC family protein-
GTF74_RS15255331438..331689+252WP_001890111.1TIGR03643 family protein-
GTF74_RS15260331662..331811+150WP_071908333.1DUF3265 domain-containing protein-
GTF74_RS15265331903..332145+243WP_000107461.1hypothetical protein-
GTF74_RS15270332397..332675+279WP_000280324.1DUF3709 domain-containing protein-
GTF74_RS15275333050..333193+144Protein_301DUF645 family protein-
GTF74_RS15280333247..333285+39WP_082798268.1hypothetical protein-
GTF74_RS15285333497..333964+468WP_001289288.1OsmC family protein-
GTF74_RS15290334092..334754+663WP_000960654.1hypothetical protein-
GTF74_RS15295334939..335205+267WP_000589156.1BrnT family toxinToxin
GTF74_RS15300335192..335437+246WP_000643598.1hypothetical proteinAntitoxin
GTF74_RS15305335533..336327+795WP_001911581.1hypothetical protein-
GTF74_RS15310336430..336558+129WP_071908338.1general secretion pathway protein GspI-
GTF74_RS15315336619..336801+183WP_000923182.1DUF645 family protein-
GTF74_RS15320337017..338021+1005WP_000964920.1LD-carboxypeptidase-
GTF74_RS15325338174..338533+360WP_001071541.1VOC family protein-
GTF74_RS15330338806..339039+234WP_001890112.1DUF3709 domain-containing protein-
GTF74_RS15335339307..339813+507WP_000393074.1hypothetical protein-
GTF74_RS15340339970..340356+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-307032..436751129719
insideIntegron--312112..436375124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T145886 WP_000589156.1 NZ_CP047304:334939-335205 [Vibrio cholerae O1 biovar El Tor]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T145886 NZ_CP062705:c4963695-4963345 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT145886 WP_000643598.1 NZ_CP047304:335192-335437 [Vibrio cholerae O1 biovar El Tor]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT145886 NZ_CP062705:c4963940-4963689 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References