56919

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 384129..384657 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag AN947_RS02185 Protein ID WP_000221354.1
Coordinates 384370..384657 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag AN947_RS02180 Protein ID WP_001250179.1
Coordinates 384129..384380 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN947_RS02130 379397..379711 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
AN947_RS02140 379848..380282 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
AN947_RS20780 380450..380605 + 156 WP_000751734.1 hypothetical protein -
AN947_RS02150 380730..381710 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
AN947_RS02155 381778..382084 + 307 Protein_387 CatB-related O-acetyltransferase -
AN947_RS02160 382221..382913 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
AN947_RS02165 382913..383314 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
AN947_RS02170 383284..383427 + 144 WP_071908341.1 DUF3265 domain-containing protein -
AN947_RS02175 383502..383915 + 414 WP_000049417.1 VOC family protein -
AN947_RS02180 384129..384380 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AN947_RS02185 384370..384657 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AN947_RS02190 384785..385240 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
AN947_RS02200 385562..385714 + 153 WP_001884520.1 DUF645 family protein -
AN947_RS02210 385916..386413 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
AN947_RS02215 386410..386682 - 273 WP_000246253.1 DUF1778 domain-containing protein -
AN947_RS02225 386913..387581 + 669 WP_000043871.1 hypothetical protein -
AN947_RS02230 387733..388020 + 288 WP_000426470.1 hypothetical protein -
AN947_RS02235 388161..388532 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
AN947_RS20785 388599..389024 + 426 WP_001882332.1 DUF1778 domain-containing protein -
AN947_RS02245 389021..389554 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791
flank IS/Tn - - 380730..381710 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T56919 WP_000221354.1 NZ_CP012666:384370-384657 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T56919 NZ_CP012666:384370-384657 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT56919 WP_001250179.1 NZ_CP012666:384129-384380 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT56919 NZ_CP012666:384129-384380 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References