Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 419968..420734 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag CSW01_RS16735 Protein ID WP_000982260.1
Coordinates 419968..420465 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag CSW01_RS16740 Protein ID WP_000246253.1
Coordinates 420462..420734 (-) Length 91 a.a.

Genomic Context

CSW01_RS16685CSW01_RS16690CSW01_RS16695CSW01_RS16700CSW01_RS16705CSW01_RS16710CSW01_RS16715CSW01_RS16720CSW01_RS16725CSW01_RS16750CSW01_RS16755CSW01_RS16760CSW01_RS20000CSW01_RS16770CSW01_RS16780CSW01_RS16785CSW01_RS16790CSW01_RS16735CSW01_RS16740
Location: 415830..416136 (307 bp)
Type: Others
Protein ID: Protein_443
Location: 416273..416965 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 416965..417366 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 417336..417479 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 417554..417967 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 418181..418432 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 418422..418709 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 418837..419292 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 419614..419766 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 420965..421633 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421785..422072 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 422213..422584 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 422651..423076 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 423073..423606 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 423808..424065 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 424053..424355 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 424589..425506 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 419968..420465 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 420462..420734 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS16685415830..416136+307Protein_443CatB-related O-acetyltransferase-
CSW01_RS16690416273..416965+693WP_001047169.1GNAT family N-acetyltransferase-
CSW01_RS16695416965..417366+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
CSW01_RS16700417336..417479+144WP_071908341.1DUF3265 domain-containing protein-
CSW01_RS16705417554..417967+414WP_000049417.1VOC family protein-
CSW01_RS16710418181..418432+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
CSW01_RS16715418422..418709+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
CSW01_RS16720418837..419292+456WP_001245327.1GNAT family N-acetyltransferase-
CSW01_RS16725419614..419766+153WP_001884520.1DUF645 family protein-
CSW01_RS16735419968..420465-498WP_000982260.1GNAT family N-acetyltransferaseToxin
CSW01_RS16740420462..420734-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
CSW01_RS16750420965..421633+669WP_000043871.1hypothetical protein-
CSW01_RS16755421785..422072+288WP_000426470.1hypothetical protein-
CSW01_RS16760422213..422584+372WP_001164080.1nucleotide pyrophosphohydrolase-
CSW01_RS20000422651..423076+426WP_001882332.1DUF1778 domain-containing protein-
CSW01_RS16770423073..423606+534WP_000118351.1GNAT family N-acetyltransferase-
CSW01_RS16780423808..424065+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
CSW01_RS16785424053..424355+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
CSW01_RS16790424589..425506+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262
flankIS/Tn--414782..415762980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T87028 WP_000982260.1 NZ_CP024163:c420465-419968 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T87028 NZ_CP024163:c420465-419968 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT87028 WP_000246253.1 NZ_CP024163:c420734-420462 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT87028 NZ_CP024163:c420734-420462 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References