145406

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 401023..401570 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GQX72_RS15965 Protein ID WP_000229317.1
Coordinates 401268..401570 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GQX72_RS15960 Protein ID WP_000861987.1
Coordinates 401023..401280 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS15905 396052..396507 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GQX72_RS15910 396829..396981 + 153 WP_001884520.1 DUF645 family protein -
GQX72_RS15920 397183..397680 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GQX72_RS15925 397677..397949 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GQX72_RS15930 398180..398848 + 669 WP_000043871.1 hypothetical protein -
GQX72_RS15935 399000..399287 + 288 WP_000426470.1 hypothetical protein -
GQX72_RS15940 399428..399799 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GQX72_RS19055 399866..400291 + 426 WP_001882332.1 DUF1778 domain-containing protein -
GQX72_RS15950 400288..400821 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
GQX72_RS15960 401023..401280 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GQX72_RS15965 401268..401570 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQX72_RS15970 401804..402721 + 918 WP_000186333.1 alpha/beta hydrolase -
GQX72_RS15975 402878..403267 + 390 WP_001081302.1 hypothetical protein -
GQX72_RS15980 403403..403612 + 210 Protein_424 GNAT family N-acetyltransferase -
GQX72_RS15985 403731..404168 + 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
GQX72_RS15990 404232..404450 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GQX72_RS15995 404625..405497 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GQX72_RS16000 405647..406246 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GQX72_RS16005 406303..406407 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743
flank IS/Tn - - 403731..404168 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145406 WP_000229317.1 NZ_CP047060:401268-401570 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145406 NZ_CP062376:2639774-2639983 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145406 WP_000861987.1 NZ_CP047060:401023-401280 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145406 NZ_CP062376:2639469-2639762 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References