Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 401023..401570 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GQX72_RS15965 Protein ID WP_000229317.1
Coordinates 401268..401570 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GQX72_RS15960 Protein ID WP_000861987.1
Coordinates 401023..401280 (+) Length 86 a.a.

Genomic Context

GQX72_RS15905GQX72_RS15910GQX72_RS15930GQX72_RS15935GQX72_RS15940GQX72_RS19055GQX72_RS15950GQX72_RS15960GQX72_RS15965GQX72_RS15970GQX72_RS15975GQX72_RS15980GQX72_RS15985GQX72_RS15990GQX72_RS15995GQX72_RS16000GQX72_RS16005GQX72_RS15920GQX72_RS15925
Location: 396052..396507 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 396829..396981 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 398180..398848 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 399000..399287 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 399428..399799 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 399866..400291 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 400288..400821 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 401023..401280 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 401268..401570 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 401804..402721 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 402878..403267 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 403403..403612 (210 bp)
Type: Others
Protein ID: Protein_424
Location: 403731..404168 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 404232..404450 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 404625..405497 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 405647..406246 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 406303..406407 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 397183..397680 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 397677..397949 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQX72_RS15905396052..396507+456WP_001245327.1GNAT family N-acetyltransferase-
GQX72_RS15910396829..396981+153WP_001884520.1DUF645 family protein-
GQX72_RS15920397183..397680-498WP_000982260.1GNAT family N-acetyltransferase-
GQX72_RS15925397677..397949-273WP_000246253.1DUF1778 domain-containing protein-
GQX72_RS15930398180..398848+669WP_000043871.1hypothetical protein-
GQX72_RS15935399000..399287+288WP_000426470.1hypothetical protein-
GQX72_RS15940399428..399799+372WP_001164080.1nucleotide pyrophosphohydrolase-
GQX72_RS19055399866..400291+426WP_001882332.1DUF1778 domain-containing protein-
GQX72_RS15950400288..400821+534WP_000118351.1GNAT family N-acetyltransferase-
GQX72_RS15960401023..401280+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GQX72_RS15965401268..401570+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GQX72_RS15970401804..402721+918WP_000186333.1alpha/beta hydrolase-
GQX72_RS15975402878..403267+390WP_001081302.1hypothetical protein-
GQX72_RS15980403403..403612+210Protein_424GNAT family N-acetyltransferase-
GQX72_RS15985403731..404168+438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
GQX72_RS15990404232..404450+219WP_071908318.1GNAT family N-acetyltransferase-
GQX72_RS15995404625..405497+873WP_000254716.1DUF3800 domain-containing protein-
GQX72_RS16000405647..406246+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GQX72_RS16005406303..406407+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305960..411159105199
insideIntegron--311040..41078399743
flankIS/Tn--403731..404168437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145406 WP_000229317.1 NZ_CP047060:401268-401570 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145406 NZ_CP062376:2639774-2639983 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145406 WP_000861987.1 NZ_CP047060:401023-401280 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145406 NZ_CP062376:2639469-2639762 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References