Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 370414..371029 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag GTF74_RS15605 Protein ID WP_001162670.1
Coordinates 370414..370701 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GTF74_RS15610 Protein ID WP_001232701.1
Coordinates 370712..371029 (+) Length 106 a.a.

Genomic Context

GTF74_RS15565GTF74_RS15580GTF74_RS15585GTF74_RS15590GTF74_RS15595GTF74_RS15600GTF74_RS15605GTF74_RS15610GTF74_RS15615GTF74_RS15620GTF74_RS15625GTF74_RS15630GTF74_RS15635GTF74_RS15640GTF74_RS15645GTF74_RS15650GTF74_RS15570GTF74_RS15575
Location: 366050..366145 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 367159..367668 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 367725..368378 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 368688..368906 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 369309..369542 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 369967..370147 (181 bp)
Type: Others
Protein ID: Protein_366
Location: 370414..370701 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 370712..371029 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 371026..371136 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 371313..371438 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 371454..371492 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 371716..372456 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 372661..373491 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 373548..374030 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 374477..375352 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 375482..375937 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 366339..366656 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 366675..366917 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF74_RS15565366050..366145+96WP_001907607.1DUF645 family protein-
GTF74_RS15570366339..366656-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF74_RS15575366675..366917-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF74_RS15580367159..367668+510WP_000405987.1GNAT family N-acetyltransferase-
GTF74_RS15585367725..368378+654WP_000226874.1hypothetical protein-
GTF74_RS15590368688..368906+219WP_001917086.1DUF3709 domain-containing protein-
GTF74_RS15595369309..369542+234WP_032482776.1DUF3709 domain-containing protein-
GTF74_RS15600369967..370147+181Protein_366DUF645 family protein-
GTF74_RS15605370414..370701+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF74_RS15610370712..371029+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
GTF74_RS15615371026..371136+111WP_134814058.1DUF3265 domain-containing protein-
GTF74_RS15620371313..371438+126WP_001944767.1DUF645 family protein-
GTF74_RS15625371454..371492+39WP_106019119.1hypothetical protein-
GTF74_RS15630371716..372456+741WP_000469836.1PhzF family phenazine biosynthesis protein-
GTF74_RS15635372661..373491+831WP_000056616.1abortive infection family protein-
GTF74_RS15640373548..374030+483WP_001895003.1hypothetical protein-
GTF74_RS15645374477..375352+876WP_000259044.1hypothetical protein-
GTF74_RS15650375482..375937+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-307032..436751129719
insideIntegron--312112..436375124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T145890 WP_001162670.1 NZ_CP047304:370414-370701 [Vibrio cholerae O1 biovar El Tor]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T145890 NZ_CP062706:71588-71746 [Escherichia coli O157:H7]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATAGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT145890 WP_001232701.1 NZ_CP047304:370712-371029 [Vibrio cholerae O1 biovar El Tor]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT145890 NZ_CP062706:71325-71523 [Escherichia coli O157:H7]
TCACACGGATTGCCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAATGTGGTCAGCGTGCTGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References