254466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 733696..734462 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag NW313_RS17130 Protein ID WP_000982260.1
Coordinates 733696..734193 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag NW313_RS17135 Protein ID WP_000246253.1
Coordinates 734190..734462 (-) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW313_RS17080 729138..729842 + 705 WP_000087610.1 HNH endonuclease -
NW313_RS17085 730000..730338 + 339 WP_000713853.1 hypothetical protein -
NW313_RS17090 730492..730809 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
NW313_RS17095 730828..731070 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NW313_RS17100 731314..731700 + 387 WP_001015867.1 NUDIX hydrolase -
NW313_RS17105 731757..731870 + 114 WP_001900214.1 hypothetical protein -
NW313_RS17110 731879..732100 + 222 WP_032467793.1 DUF1289 domain-containing protein -
NW313_RS17115 732358..732894 + 537 WP_000469482.1 GNAT family protein -
NW313_RS17120 733085..733546 + 462 WP_001903091.1 lipocalin family protein -
NW313_RS17125 733611..733679 + 69 Protein_648 acetyltransferase -
NW313_RS17130 733696..734193 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
NW313_RS17135 734190..734462 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
NW313_RS17140 734855..734980 + 126 WP_001900195.1 DUF645 family protein -
NW313_RS17145 735230..735676 + 447 WP_000006157.1 hypothetical protein -
NW313_RS17150 735739..736950 + 1212 WP_001122813.1 IS256 family transposase -
NW313_RS17155 737137..737406 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
NW313_RS17160 737399..737677 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
NW313_RS17165 737728..737845 + 118 Protein_656 DUF3265 domain-containing protein -
NW313_RS17170 737963..738241 + 279 WP_001921601.1 DUF3709 domain-containing protein -
NW313_RS17175 738601..738699 + 99 WP_223225486.1 DUF3709 domain-containing protein -
NW313_RS17180 738899..739000 + 102 WP_001921603.1 hypothetical protein -
NW313_RS17185 738990..739376 + 387 WP_000703163.1 VOC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 713852..820357 106505
inside Integron catB9 - 718932..819981 101049
- flank IS/Tn - - 735739..736950 1211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(86-152)

Antitoxin

(7-86)


Sequences


Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T254466 WP_000982260.1 NZ_CP102928:c734193-733696 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp


Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT254466 WP_000246253.1 NZ_CP102928:c734462-734190 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1


Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References