Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /GNAT-DUF1778 |
Location | 733696..734462 | Replicon | chromosome |
Accession | NZ_CP102928 | ||
Organism | Vibrio cholerae strain N1252 |
Toxin (Protein)
Gene name | - | Uniprot ID | Q9K2P7 |
Locus tag | NW313_RS17130 | Protein ID | WP_000982260.1 |
Coordinates | 733696..734193 (-) | Length | 166 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | Q9K2J6 |
Locus tag | NW313_RS17135 | Protein ID | WP_000246253.1 |
Coordinates | 734190..734462 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NW313_RS17080 | 729138..729842 | + | 705 | WP_000087610.1 | HNH endonuclease | - |
NW313_RS17085 | 730000..730338 | + | 339 | WP_000713853.1 | hypothetical protein | - |
NW313_RS17090 | 730492..730809 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
NW313_RS17095 | 730828..731070 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
NW313_RS17100 | 731314..731700 | + | 387 | WP_001015867.1 | NUDIX hydrolase | - |
NW313_RS17105 | 731757..731870 | + | 114 | WP_001900214.1 | hypothetical protein | - |
NW313_RS17110 | 731879..732100 | + | 222 | WP_032467793.1 | DUF1289 domain-containing protein | - |
NW313_RS17115 | 732358..732894 | + | 537 | WP_000469482.1 | GNAT family protein | - |
NW313_RS17120 | 733085..733546 | + | 462 | WP_001903091.1 | lipocalin family protein | - |
NW313_RS17125 | 733611..733679 | + | 69 | Protein_648 | acetyltransferase | - |
NW313_RS17130 | 733696..734193 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | Toxin |
NW313_RS17135 | 734190..734462 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | Antitoxin |
NW313_RS17140 | 734855..734980 | + | 126 | WP_001900195.1 | DUF645 family protein | - |
NW313_RS17145 | 735230..735676 | + | 447 | WP_000006157.1 | hypothetical protein | - |
NW313_RS17150 | 735739..736950 | + | 1212 | WP_001122813.1 | IS256 family transposase | - |
NW313_RS17155 | 737137..737406 | - | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | - |
NW313_RS17160 | 737399..737677 | - | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
NW313_RS17165 | 737728..737845 | + | 118 | Protein_656 | DUF3265 domain-containing protein | - |
NW313_RS17170 | 737963..738241 | + | 279 | WP_001921601.1 | DUF3709 domain-containing protein | - |
NW313_RS17175 | 738601..738699 | + | 99 | WP_223225486.1 | DUF3709 domain-containing protein | - |
NW313_RS17180 | 738899..739000 | + | 102 | WP_001921603.1 | hypothetical protein | - |
NW313_RS17185 | 738990..739376 | + | 387 | WP_000703163.1 | VOC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 713852..820357 | 106505 | |
inside | Integron | catB9 | - | 718932..819981 | 101049 | ||
- | flank | IS/Tn | - | - | 735739..736950 | 1211 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18527.18 Da Isoelectric Point: 8.7753
>T254466 WP_000982260.1 NZ_CP102928:c734193-733696 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Q0KGB1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0F2IC79 |