Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 814810..815425 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag A6J62_RS04045 Protein ID WP_001162670.1
Coordinates 815138..815425 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A6J62_RS04040 Protein ID WP_001232701.1
Coordinates 814810..815127 (-) Length 106 a.a.

Genomic Context

A6J62_RS04075A6J62_RS04080A6J62_RS03990A6J62_RS03995A6J62_RS04005A6J62_RS04010A6J62_RS04015A6J62_RS19570A6J62_RS04025A6J62_RS19670A6J62_RS04040A6J62_RS04045A6J62_RS04050A6J62_RS04055A6J62_RS04060A6J62_RS04065A6J62_RS04070A6J62_RS19675
Location: 818922..819164 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 819183..819500 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 809902..810357 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 810487..811362 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 811809..812291 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 812348..813178 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 813383..814123 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 814347..814385 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 814401..814526 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 814703..814813 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 814810..815127 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 815138..815425 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 815692..815872 (181 bp)
Type: Others
Protein ID: Protein_750
Location: 816297..816530 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 816933..817151 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 817461..818114 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 818171..818680 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 819694..819789 (96 bp)
Type: Others
Protein ID: WP_001907607.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A6J62_RS03990809902..810357-456WP_001245327.1GNAT family N-acetyltransferase-
A6J62_RS03995810487..811362-876WP_000259044.1hypothetical protein-
A6J62_RS04005811809..812291-483WP_001895003.1hypothetical protein-
A6J62_RS04010812348..813178-831WP_000056616.1abortive infection family protein-
A6J62_RS04015813383..814123-741WP_000469836.1PhzF family phenazine biosynthesis protein-
A6J62_RS19570814347..814385-39WP_106019119.1hypothetical protein-
A6J62_RS04025814401..814526-126WP_001944767.1DUF645 family protein-
A6J62_RS19670814703..814813-111WP_134814058.1DUF3265 domain-containing protein-
A6J62_RS04040814810..815127-318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
A6J62_RS04045815138..815425-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A6J62_RS04050815692..815872-181Protein_750DUF645 family protein-
A6J62_RS04055816297..816530-234WP_032482776.1DUF3709 domain-containing protein-
A6J62_RS04060816933..817151-219WP_001917086.1DUF3709 domain-containing protein-
A6J62_RS04065817461..818114-654WP_000226874.1hypothetical protein-
A6J62_RS04070818171..818680-510WP_000405987.1GNAT family N-acetyltransferase-
A6J62_RS04075818922..819164+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
A6J62_RS04080819183..819500+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
A6J62_RS19675819694..819789-96WP_001907607.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-749087..881909132822
insideIntegron--749463..875103125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T74624 WP_001162670.1 NZ_CP020407:c815425-815138 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T74624 NZ_CP020407:c815425-815138 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT74624 WP_001232701.1 NZ_CP020407:c815127-814810 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT74624 NZ_CP020407:c815127-814810 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References