145825

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 328873..329413 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag GTF73_RS15240 Protein ID WP_000277238.1
Coordinates 328873..329142 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag GTF73_RS15245 Protein ID WP_001258569.1
Coordinates 329135..329413 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS15180 323877..324119 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF73_RS15185 324363..324749 + 387 WP_001015867.1 NUDIX hydrolase -
GTF73_RS15190 324806..324919 + 114 WP_001900214.1 hypothetical protein -
GTF73_RS15195 324868..325149 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GTF73_RS15200 325125..325283 - 159 WP_001886450.1 DUF1196 family protein -
GTF73_RS15205 325407..325943 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF73_RS15210 326080..326595 + 516 WP_001201509.1 lipocalin family protein -
GTF73_RS15215 326745..327242 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF73_RS15220 327239..327511 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF73_RS15225 327904..328029 + 126 WP_001900195.1 DUF645 family protein -
GTF73_RS15230 328045..328083 + 39 WP_106019118.1 hypothetical protein -
GTF73_RS15235 328279..328725 + 447 WP_000006157.1 hypothetical protein -
GTF73_RS15240 328873..329142 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
GTF73_RS15245 329135..329413 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTF73_RS15250 329699..329977 + 279 WP_001921601.1 DUF3709 domain-containing protein -
GTF73_RS15255 330229..330435 + 207 Protein_294 DUF3709 domain-containing protein -
GTF73_RS15260 330635..330736 + 102 WP_001921603.1 hypothetical protein -
GTF73_RS15265 330726..331112 + 387 WP_000703163.1 VOC family protein -
GTF73_RS15270 331307..331558 + 252 WP_001890111.1 TIGR03643 family protein -
GTF73_RS15275 331531..331680 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF73_RS15280 331772..332014 + 243 WP_000107461.1 hypothetical protein -
GTF73_RS15285 332266..332544 + 279 WP_000280324.1 DUF3709 domain-containing protein -
GTF73_RS15290 332919..333062 + 144 Protein_301 DUF645 family protein -
GTF73_RS15295 333116..333154 + 39 WP_082798268.1 hypothetical protein -
GTF73_RS15300 333366..333833 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T145825 WP_000277238.1 NZ_CP047298:c329142-328873 [Vibrio cholerae O1 biovar El Tor]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T145825 NZ_CP062700:4802031-4802372 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT145825 WP_001258569.1 NZ_CP047298:c329413-329135 [Vibrio cholerae O1 biovar El Tor]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT145825 NZ_CP062700:c4802036-4801960 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References