Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 328873..329413 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag GTF73_RS15240 Protein ID WP_000277238.1
Coordinates 328873..329142 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag GTF73_RS15245 Protein ID WP_001258569.1
Coordinates 329135..329413 (-) Length 93 a.a.

Genomic Context

GTF73_RS15185GTF73_RS15190GTF73_RS15195GTF73_RS15205GTF73_RS15210GTF73_RS15225GTF73_RS15230GTF73_RS15235GTF73_RS15250GTF73_RS15255GTF73_RS15260GTF73_RS15265GTF73_RS15270GTF73_RS15275GTF73_RS15280GTF73_RS15285GTF73_RS15290GTF73_RS15295GTF73_RS15300GTF73_RS15180GTF73_RS15200GTF73_RS15215GTF73_RS15220GTF73_RS15240GTF73_RS15245
Location: 324363..324749 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 324806..324919 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324868..325149 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 325407..325943 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 326080..326595 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 327904..328029 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 328045..328083 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 328279..328725 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 329699..329977 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 330229..330435 (207 bp)
Type: Others
Protein ID: Protein_294
Location: 330635..330736 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 330726..331112 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 331307..331558 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 331531..331680 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 331772..332014 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 332266..332544 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332919..333062 (144 bp)
Type: Others
Protein ID: Protein_301
Location: 333116..333154 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 333366..333833 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 323877..324119 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 325125..325283 (159 bp)
Type: Others
Protein ID: WP_001886450.1
Location: 326745..327242 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 327239..327511 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 328873..329142 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 329135..329413 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF73_RS15180323877..324119-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF73_RS15185324363..324749+387WP_001015867.1NUDIX hydrolase-
GTF73_RS15190324806..324919+114WP_001900214.1hypothetical protein-
GTF73_RS15195324868..325149+282WP_001894429.1DUF1289 domain-containing protein-
GTF73_RS15200325125..325283-159WP_001886450.1DUF1196 family protein-
GTF73_RS15205325407..325943+537WP_000469482.1GNAT family N-acetyltransferase-
GTF73_RS15210326080..326595+516WP_001201509.1lipocalin family protein-
GTF73_RS15215326745..327242-498WP_000982260.1GNAT family N-acetyltransferase-
GTF73_RS15220327239..327511-273WP_000246253.1DUF1778 domain-containing protein-
GTF73_RS15225327904..328029+126WP_001900195.1DUF645 family protein-
GTF73_RS15230328045..328083+39WP_106019118.1hypothetical protein-
GTF73_RS15235328279..328725+447WP_000006157.1hypothetical protein-
GTF73_RS15240328873..329142-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
GTF73_RS15245329135..329413-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GTF73_RS15250329699..329977+279WP_001921601.1DUF3709 domain-containing protein-
GTF73_RS15255330229..330435+207Protein_294DUF3709 domain-containing protein-
GTF73_RS15260330635..330736+102WP_001921603.1hypothetical protein-
GTF73_RS15265330726..331112+387WP_000703163.1VOC family protein-
GTF73_RS15270331307..331558+252WP_001890111.1TIGR03643 family protein-
GTF73_RS15275331531..331680+150WP_071908333.1DUF3265 domain-containing protein-
GTF73_RS15280331772..332014+243WP_000107461.1hypothetical protein-
GTF73_RS15285332266..332544+279WP_000280324.1DUF3709 domain-containing protein-
GTF73_RS15290332919..333062+144Protein_301DUF645 family protein-
GTF73_RS15295333116..333154+39WP_082798268.1hypothetical protein-
GTF73_RS15300333366..333833+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306901..436162129261
insideIntegron--311981..435786123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T145825 WP_000277238.1 NZ_CP047298:c329142-328873 [Vibrio cholerae O1 biovar El Tor]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T145825 NZ_CP062700:4802031-4802372 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT145825 WP_001258569.1 NZ_CP047298:c329413-329135 [Vibrio cholerae O1 biovar El Tor]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT145825 NZ_CP062700:c4802036-4801960 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References