Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 421606..422372 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag O3Y_RS16190 Protein ID WP_000982260.1
Coordinates 421606..422103 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag O3Y_RS16195 Protein ID WP_000246253.1
Coordinates 422100..422372 (-) Length 91 a.a.

Genomic Context

O3Y_RS16150O3Y_RS16155O3Y_RS16160O3Y_RS20335O3Y_RS16165O3Y_RS16170O3Y_RS16175O3Y_RS16180O3Y_RS16185O3Y_RS16200O3Y_RS16205O3Y_RS16210O3Y_RS16215O3Y_RS16220O3Y_RS16225O3Y_RS16230O3Y_RS16235O3Y_RS16190O3Y_RS16195
Location: 417468..417774 (307 bp)
Type: Others
Protein ID: Protein_444
Location: 417911..418603 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 418603..419004 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 418974..419117 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419192..419605 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 419819..420070 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420060..420347 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 420475..420930 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421252..421404 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 422603..423271 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 423423..423710 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 423851..424222 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424289..424714 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 424711..425244 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 425446..425703 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 425691..425993 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 426227..427144 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 421606..422103 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 422100..422372 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS16150417468..417774+307Protein_444CatB-related O-acetyltransferase-
O3Y_RS16155417911..418603+693WP_001047169.1GNAT family N-acetyltransferase-
O3Y_RS16160418603..419004+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
O3Y_RS20335418974..419117+144WP_071908341.1DUF3265 domain-containing protein-
O3Y_RS16165419192..419605+414WP_000049417.1VOC family protein-
O3Y_RS16170419819..420070+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
O3Y_RS16175420060..420347+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
O3Y_RS16180420475..420930+456WP_001245327.1GNAT family N-acetyltransferase-
O3Y_RS16185421252..421404+153WP_001884520.1DUF645 family protein-
O3Y_RS16190421606..422103-498WP_000982260.1GNAT family N-acetyltransferaseToxin
O3Y_RS16195422100..422372-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
O3Y_RS16200422603..423271+669WP_000043871.1hypothetical protein-
O3Y_RS16205423423..423710+288WP_000426470.1hypothetical protein-
O3Y_RS16210423851..424222+372WP_001164080.1nucleotide pyrophosphohydrolase-
O3Y_RS16215424289..424714+426WP_001882332.1DUF1778 domain-containing protein-
O3Y_RS16220424711..425244+534WP_000118351.1GNAT family N-acetyltransferase-
O3Y_RS16225425446..425703+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
O3Y_RS16230425691..425993+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
O3Y_RS16235426227..427144+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489
flankIS/Tn--416420..417400980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T26155 WP_000982260.1 NC_016945:c422103-421606 [Vibrio cholerae IEC224]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T26155 NC_016945:c422103-421606 [Vibrio cholerae IEC224]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT26155 WP_000246253.1 NC_016945:c422372-422100 [Vibrio cholerae IEC224]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT26155 NC_016945:c422372-422100 [Vibrio cholerae IEC224]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References