Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 845232..845779 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag LZM82_RS17290 Protein ID WP_000229317.1
Coordinates 845232..845534 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag LZM82_RS17295 Protein ID WP_000861987.1
Coordinates 845522..845779 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17250 (LZM82_17250) 840431..840499 - 69 Protein_717 acetyltransferase -
LZM82_RS17255 (LZM82_17255) 840556..841155 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
LZM82_RS17260 (LZM82_17260) 841305..842177 - 873 WP_000254716.1 DUF3800 domain-containing protein -
LZM82_RS17265 (LZM82_17265) 842352..842573 - 222 Protein_720 GNAT family N-acetyltransferase -
LZM82_RS17270 (LZM82_17270) 842634..843071 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
LZM82_RS17275 (LZM82_17275) 843190..843399 - 210 Protein_722 GNAT family N-acetyltransferase -
LZM82_RS17280 (LZM82_17280) 843535..843924 - 390 WP_001081302.1 hypothetical protein -
LZM82_RS17285 (LZM82_17285) 844081..844998 - 918 WP_000186333.1 alpha/beta hydrolase -
LZM82_RS17290 (LZM82_17290) 845232..845534 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZM82_RS17295 (LZM82_17295) 845522..845779 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LZM82_RS17300 (LZM82_17300) 845861..845971 - 111 WP_086010065.1 DUF3265 domain-containing protein -
LZM82_RS17305 (LZM82_17305) 845981..846514 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
LZM82_RS17310 (LZM82_17310) 846511..846780 - 270 WP_000179600.1 DUF1778 domain-containing protein -
LZM82_RS17315 (LZM82_17315) 847003..847374 - 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
LZM82_RS17320 (LZM82_17320) 847515..847802 - 288 WP_000426470.1 hypothetical protein -
LZM82_RS17325 (LZM82_17325) 847954..848622 - 669 WP_000043871.1 hypothetical protein -
LZM82_RS17330 (LZM82_17330) 848639..848701 - 63 Protein_733 acetyltransferase -
LZM82_RS17335 (LZM82_17335) 848853..849125 + 273 WP_000246253.1 DUF1778 domain-containing protein -
LZM82_RS17340 (LZM82_17340) 849122..849619 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
LZM82_RS17345 (LZM82_17345) 849636..849704 - 69 Protein_736 acetyltransferase -
LZM82_RS17350 (LZM82_17350) 849821..849925 - 105 WP_228840819.1 DUF645 family protein -
LZM82_RS17360 (LZM82_17360) 850116..850238 - 123 Protein_738 acetyltransferase -
LZM82_RS17365 (LZM82_17365) 850295..850750 - 456 WP_001245327.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049
flank IS/Tn - - 842634..843071 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T230637 WP_000229317.1 NZ_CP090400:c845534-845232 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T230637 NZ_CP125220:c4072698-4072414 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT230637 WP_000861987.1 NZ_CP090400:c845779-845522 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT230637 NZ_CP125220:c4072930-4072688 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References