Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 379078..379711 | Replicon | chromosome |
| Accession | NZ_CP012666 | ||
| Organism | Vibrio cholerae strain ICDC-VC661 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | AN947_RS02125 | Protein ID | WP_000843587.1 |
| Coordinates | 379078..379410 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | AN947_RS02130 | Protein ID | WP_000071008.1 |
| Coordinates | 379397..379711 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AN947_RS20765 | 374519..374722 | + | 204 | WP_001911745.1 | hypothetical protein | - |
| AN947_RS20770 | 375003..375176 | + | 174 | WP_001882305.1 | DUF3709 domain-containing protein | - |
| AN947_RS02060 | 375536..375805 | + | 270 | WP_001198131.1 | hypothetical protein | - |
| AN947_RS02070 | 376123..376294 | + | 172 | Protein_374 | DUF645 family protein | - |
| AN947_RS02075 | 376503..376889 | + | 387 | WP_000703163.1 | VOC family protein | - |
| AN947_RS02080 | 377091..377333 | + | 243 | WP_000107461.1 | hypothetical protein | - |
| AN947_RS02085 | 377504..377881 | + | 378 | WP_000411109.1 | hypothetical protein | - |
| AN947_RS20775 | 377938..378052 | + | 115 | Protein_378 | acetyltransferase | - |
| AN947_RS02090 | 378001..378282 | + | 282 | WP_001894453.1 | DUF1289 domain-containing protein | - |
| AN947_RS02105 | 378448..378561 | + | 114 | WP_001889158.1 | hypothetical protein | - |
| AN947_RS02110 | 378510..378737 | + | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
| AN947_RS02125 | 379078..379410 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AN947_RS02130 | 379397..379711 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| AN947_RS02140 | 379848..380282 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
| AN947_RS20780 | 380450..380605 | + | 156 | WP_000751734.1 | hypothetical protein | - |
| AN947_RS02150 | 380730..381710 | - | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
| AN947_RS02155 | 381778..382084 | + | 307 | Protein_387 | CatB-related O-acetyltransferase | - |
| AN947_RS02160 | 382221..382913 | + | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
| AN947_RS02165 | 382913..383314 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| AN947_RS02170 | 383284..383427 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| AN947_RS02175 | 383502..383915 | + | 414 | WP_000049417.1 | VOC family protein | - |
| AN947_RS02180 | 384129..384380 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| AN947_RS02185 | 384370..384657 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 304645..399892 | 95247 | |
| inside | Integron | - | - | 309725..399516 | 89791 | ||
| flank | IS/Tn | - | - | 380730..381710 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T56917 WP_000843587.1 NZ_CP012666:379078-379410 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T56917 NZ_CP012666:379078-379410 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT56917 WP_000071008.1 NZ_CP012666:379397-379711 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT56917 NZ_CP012666:379397-379711 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|