230646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 896713..897251 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag LZM82_RS17815 Protein ID WP_000802136.1
Coordinates 896952..897251 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag LZM82_RS17810 Protein ID WP_001107719.1
Coordinates 896713..896955 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17775 (LZM82_17775) 892129..892269 - 141 WP_001883049.1 DUF3265 domain-containing protein -
LZM82_RS17780 (LZM82_17780) 892235..893170 - 936 WP_000051985.1 restriction endonuclease -
LZM82_RS17785 (LZM82_17785) 893451..894050 - 600 WP_000429495.1 DUF6338 family protein -
LZM82_RS17790 (LZM82_17790) 894205..894471 - 267 WP_000937852.1 hypothetical protein -
LZM82_RS17795 (LZM82_17795) 894685..895368 - 684 WP_000877436.1 hypothetical protein -
LZM82_RS17800 (LZM82_17800) 895792..895884 - 93 WP_014164112.1 DUF3265 domain-containing protein -
LZM82_RS17805 (LZM82_17805) 895906..896484 - 579 WP_000110120.1 hypothetical protein -
LZM82_RS17810 (LZM82_17810) 896713..896955 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LZM82_RS17815 (LZM82_17815) 896952..897251 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZM82_RS17820 (LZM82_17820) 897379..897774 - 396 WP_000870857.1 DUF3465 domain-containing protein -
LZM82_RS17825 (LZM82_17825) 897988..898167 - 180 WP_001883058.1 DUF645 family protein -
LZM82_RS17830 (LZM82_17830) 898745..898834 - 90 WP_072606010.1 DUF3265 domain-containing protein -
LZM82_RS17835 (LZM82_17835) 898865..899563 - 699 WP_001890502.1 hypothetical protein -
LZM82_RS17840 (LZM82_17840) 899686..900312 - 627 WP_000365424.1 LysE family translocator -
LZM82_RS17845 (LZM82_17845) 900354..900446 - 93 WP_014378730.1 DUF3265 domain-containing protein -
LZM82_RS17850 (LZM82_17850) 900461..900934 - 474 WP_001161076.1 GrpB family protein -
LZM82_RS17855 (LZM82_17855) 901134..901316 - 183 WP_000923182.1 DUF645 family protein -
LZM82_RS17860 (LZM82_17860) 901377..901514 - 138 WP_001890145.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T230646 WP_000802136.1 NZ_CP090400:896952-897251 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T230646 NZ_CP125225:456078-456467 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT230646 WP_001107719.1 NZ_CP090400:896713-896955 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT230646 NZ_CP125225:455814-456071 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References