Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 896713..897251 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag LZM82_RS17815 Protein ID WP_000802136.1
Coordinates 896952..897251 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag LZM82_RS17810 Protein ID WP_001107719.1
Coordinates 896713..896955 (+) Length 81 a.a.

Genomic Context

LZM82_RS17810LZM82_RS17815LZM82_RS17775LZM82_RS17780LZM82_RS17785LZM82_RS17790LZM82_RS17795LZM82_RS17800LZM82_RS17805LZM82_RS17820LZM82_RS17825LZM82_RS17830LZM82_RS17835LZM82_RS17840LZM82_RS17845LZM82_RS17850LZM82_RS17855LZM82_RS17860
Location: 896713..896955 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
Location: 896952..897251 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 892129..892269 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 892235..893170 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 893451..894050 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 894205..894471 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 894685..895368 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 895792..895884 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 895906..896484 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 897379..897774 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 897988..898167 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 898745..898834 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 898865..899563 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 899686..900312 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 900354..900446 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 900461..900934 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 901134..901316 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 901377..901514 (138 bp)
Type: Others
Protein ID: WP_001890145.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZM82_RS17775 (LZM82_17775)892129..892269-141WP_001883049.1DUF3265 domain-containing protein-
LZM82_RS17780 (LZM82_17780)892235..893170-936WP_000051985.1restriction endonuclease-
LZM82_RS17785 (LZM82_17785)893451..894050-600WP_000429495.1DUF6338 family protein-
LZM82_RS17790 (LZM82_17790)894205..894471-267WP_000937852.1hypothetical protein-
LZM82_RS17795 (LZM82_17795)894685..895368-684WP_000877436.1hypothetical protein-
LZM82_RS17800 (LZM82_17800)895792..895884-93WP_014164112.1DUF3265 domain-containing protein-
LZM82_RS17805 (LZM82_17805)895906..896484-579WP_000110120.1hypothetical protein-
LZM82_RS17810 (LZM82_17810)896713..896955+243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
LZM82_RS17815 (LZM82_17815)896952..897251+300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LZM82_RS17820 (LZM82_17820)897379..897774-396WP_000870857.1DUF3465 domain-containing protein-
LZM82_RS17825 (LZM82_17825)897988..898167-180WP_001883058.1DUF645 family protein-
LZM82_RS17830 (LZM82_17830)898745..898834-90WP_072606010.1DUF3265 domain-containing protein-
LZM82_RS17835 (LZM82_17835)898865..899563-699WP_001890502.1hypothetical protein-
LZM82_RS17840 (LZM82_17840)899686..900312-627WP_000365424.1LysE family translocator-
LZM82_RS17845 (LZM82_17845)900354..900446-93WP_014378730.1DUF3265 domain-containing protein-
LZM82_RS17850 (LZM82_17850)900461..900934-474WP_001161076.1GrpB family protein-
LZM82_RS17855 (LZM82_17855)901134..901316-183WP_000923182.1DUF645 family protein-
LZM82_RS17860 (LZM82_17860)901377..901514-138WP_001890145.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-835643..943910108267
insideIntegron--836019..937068101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T230646 WP_000802136.1 NZ_CP090400:896952-897251 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T230646 NZ_CP125225:456078-456467 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT230646 WP_001107719.1 NZ_CP090400:896713-896955 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT230646 NZ_CP125225:455814-456071 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References