Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 399707..400235 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag A1552VC_RS16565 Protein ID WP_000221352.1
Coordinates 399707..399997 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag A1552VC_RS16570 Protein ID WP_000213183.1
Coordinates 399987..400235 (-) Length 83 a.a.

Genomic Context

A1552VC_RS20130A1552VC_RS20135A1552VC_RS16535A1552VC_RS16540A1552VC_RS16545A1552VC_RS16550A1552VC_RS16555A1552VC_RS16560A1552VC_RS16585A1552VC_RS16590A1552VC_RS16595A1552VC_RS16600A1552VC_RS16605A1552VC_RS16615A1552VC_RS16565A1552VC_RS16570A1552VC_RS16620
Location: 395264..395389 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 395405..395443 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 395656..396660 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 396813..397259 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 397379..398308 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 398305..398415 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 398443..398919 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 399056..399571 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 400806..401459 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 401731..402156 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 402364..402759 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 402910..403440 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 403578..404078 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 404234..404632 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 399707..399997 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 399987..400235 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 404732..405196 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A1552VC_RS20130395264..395389+126WP_001944767.1DUF645 family protein-
A1552VC_RS20135395405..395443+39WP_106019119.1hypothetical protein-
A1552VC_RS16535395656..396660+1005WP_000964925.1LD-carboxypeptidase-
A1552VC_RS16540396813..397259+447WP_000128977.1hypothetical protein-
A1552VC_RS16545397379..398308+930WP_000335802.1hypothetical protein-
A1552VC_RS16550398305..398415+111WP_071917832.1DUF3265 domain-containing protein-
A1552VC_RS16555398443..398919+477WP_001047180.1GNAT family N-acetyltransferase-
A1552VC_RS16560399056..399571+516WP_001201528.1lipocalin family protein-
A1552VC_RS16565399707..399997-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A1552VC_RS16570399987..400235-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
A1552VC_RS16585400806..401459+654WP_000036957.1site-specific DNA-methyltransferase-
A1552VC_RS16590401731..402156+426WP_000415748.1hypothetical protein-
A1552VC_RS16595402364..402759+396WP_000649527.1DUF3465 domain-containing protein-
A1552VC_RS16600402910..403440+531WP_000415563.1hypothetical protein-
A1552VC_RS16605403578..404078+501WP_000789723.1hypothetical protein-
A1552VC_RS16615404234..404632+399WP_001882293.1hypothetical protein-
A1552VC_RS16620404732..405196-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T104343 WP_000221352.1 NZ_CP028895:c399997-399707 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T104343 NZ_CP028895:c399997-399707 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT104343 WP_000213183.1 NZ_CP028895:c400235-399987 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT104343 NZ_CP028895:c400235-399987 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References