Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 425625..426172 Replicon chromosome
Accession NZ_LT906615
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag FY484_RS16485 Protein ID WP_000229317.1
Coordinates 425870..426172 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag FY484_RS16480 Protein ID WP_000861987.1
Coordinates 425625..425882 (+) Length 86 a.a.

Genomic Context

FY484_RS16425FY484_RS16430FY484_RS16450FY484_RS16455FY484_RS16460FY484_RS19570FY484_RS16470FY484_RS16480FY484_RS16485FY484_RS16490FY484_RS16495FY484_RS16500FY484_RS16505FY484_RS16510FY484_RS16515FY484_RS16520FY484_RS16525FY484_RS16440FY484_RS16445
Location: 420654..421109 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421431..421583 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 422782..423450 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 423602..423889 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424030..424401 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424468..424893 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 424890..425423 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 425625..425882 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 425870..426172 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 426406..427323 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427480..427869 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428005..428214 (210 bp)
Type: Others
Protein ID: Protein_466
Location: 428333..428770 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 428834..429052 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429227..430099 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430249..430848 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 430905..431009 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 421785..422282 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422279..422551 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FY484_RS16425420654..421109+456WP_001245327.1GNAT family N-acetyltransferase-
FY484_RS16430421431..421583+153WP_001884520.1DUF645 family protein-
FY484_RS16440421785..422282-498WP_000982260.1GNAT family N-acetyltransferase-
FY484_RS16445422279..422551-273WP_000246253.1DUF1778 domain-containing protein-
FY484_RS16450422782..423450+669WP_000043871.1hypothetical protein-
FY484_RS16455423602..423889+288WP_000426470.1hypothetical protein-
FY484_RS16460424030..424401+372WP_001164080.1nucleotide pyrophosphohydrolase-
FY484_RS19570424468..424893+426WP_001882332.1DUF1778 domain-containing protein-
FY484_RS16470424890..425423+534WP_000118351.1GNAT family N-acetyltransferase-
FY484_RS16480425625..425882+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
FY484_RS16485425870..426172+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FY484_RS16490426406..427323+918WP_000186333.1alpha/beta hydrolase-
FY484_RS16495427480..427869+390WP_001081302.1hypothetical protein-
FY484_RS16500428005..428214+210Protein_466GNAT family N-acetyltransferase-
FY484_RS16505428333..428770+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
FY484_RS16510428834..429052+219WP_071908318.1GNAT family N-acetyltransferase-
FY484_RS16515429227..430099+873WP_000254716.1DUF3800 domain-containing protein-
FY484_RS16520430249..430848+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
FY484_RS16525430905..431009+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639
flankIS/Tn--428333..428770437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T293806 WP_000229317.1 NZ_LT906615:425870-426172 [Vibrio cholerae O1 biovar El Tor str. N16961]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT293806 WP_000861987.1 NZ_LT906615:425625-425882 [Vibrio cholerae O1 biovar El Tor str. N16961]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References