Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 415269..415797 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag DG176_RS16390 Protein ID WP_000221352.1
Coordinates 415507..415797 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag DG176_RS16385 Protein ID WP_000213183.1
Coordinates 415269..415517 (+) Length 83 a.a.

Genomic Context

DG176_RS16335DG176_RS16385DG176_RS16390DG176_RS16340DG176_RS16350DG176_RS16355DG176_RS16360DG176_RS16365DG176_RS16370DG176_RS16395DG176_RS16400DG176_RS16405DG176_RS16410DG176_RS16415DG176_RS16420DG176_RS19810DG176_RS19815DG176_RS19820
Location: 410304..410768 (465 bp)
Type: Others
Protein ID: WP_000140244.1
Location: 415269..415517 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 415507..415797 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 410868..411270 (403 bp)
Type: Others
Protein ID: Protein_373
Location: 411426..411926 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 412064..412594 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 412745..413140 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 413348..413773 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 414045..414698 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 415933..416448 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 416585..417061 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 417089..417199 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 417196..418125 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 418245..418691 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 418844..419848 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 420061..420099 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 420115..420240 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 420417..420527 (111 bp)
Type: Others
Protein ID: WP_134814058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG176_RS16335410304..410768+465WP_000140244.1hypothetical protein-
DG176_RS16340410868..411270-403Protein_373hypothetical protein-
DG176_RS16350411426..411926-501WP_000789723.1hypothetical protein-
DG176_RS16355412064..412594-531WP_000415563.1hypothetical protein-
DG176_RS16360412745..413140-396WP_000649527.1DUF3465 domain-containing protein-
DG176_RS16365413348..413773-426WP_000415748.1hypothetical protein-
DG176_RS16370414045..414698-654WP_000036957.1site-specific DNA-methyltransferase-
DG176_RS16385415269..415517+249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
DG176_RS16390415507..415797+291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG176_RS16395415933..416448-516WP_001201528.1lipocalin family protein-
DG176_RS16400416585..417061-477WP_001047180.1GNAT family N-acetyltransferase-
DG176_RS16405417089..417199-111WP_071917832.1DUF3265 domain-containing protein-
DG176_RS16410417196..418125-930WP_000335802.1hypothetical protein-
DG176_RS16415418245..418691-447WP_000128977.1hypothetical protein-
DG176_RS16420418844..419848-1005WP_000964925.1LD-carboxypeptidase-
DG176_RS19810420061..420099-39WP_106019119.1hypothetical protein-
DG176_RS19815420115..420240-126WP_001944767.1DUF645 family protein-
DG176_RS19820420417..420527-111WP_134814058.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-379325..47629796972
insideIntegroncatB9-379701..46950989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T294377 WP_000221352.1 NZ_LT992489:415507-415797 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT294377 WP_000213183.1 NZ_LT992489:415269-415517 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References