Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 938724..939339 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag DG247_RS18755 Protein ID WP_001162670.1
Coordinates 939052..939339 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DG247_RS18750 Protein ID WP_001232701.1
Coordinates 938724..939041 (-) Length 106 a.a.

Genomic Context

DG247_RS18785DG247_RS18790DG247_RS18700DG247_RS18705DG247_RS18710DG247_RS18715DG247_RS18720DG247_RS18725DG247_RS19820DG247_RS19825DG247_RS19830DG247_RS18750DG247_RS18755DG247_RS18760DG247_RS18765DG247_RS18770DG247_RS18775DG247_RS18780DG247_RS19835
Location: 942836..943078 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 943097..943414 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 934133..934648 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 934785..935261 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 935289..935399 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 935396..936325 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 936445..936891 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 937044..938048 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 938261..938299 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 938315..938440 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 938617..938727 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 938724..939041 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 939052..939339 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 939606..939786 (181 bp)
Type: Others
Protein ID: Protein_830
Location: 940211..940444 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 940847..941065 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 941375..942028 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 942085..942594 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 943608..943703 (96 bp)
Type: Others
Protein ID: WP_001907607.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG247_RS18700934133..934648-516WP_001201528.1lipocalin family protein-
DG247_RS18705934785..935261-477WP_001047180.1GNAT family N-acetyltransferase-
DG247_RS18710935289..935399-111WP_071917832.1DUF3265 domain-containing protein-
DG247_RS18715935396..936325-930WP_000335802.1hypothetical protein-
DG247_RS18720936445..936891-447WP_000128977.1hypothetical protein-
DG247_RS18725937044..938048-1005WP_000964925.1LD-carboxypeptidase-
DG247_RS19820938261..938299-39WP_106019119.1hypothetical protein-
DG247_RS19825938315..938440-126WP_001944767.1DUF645 family protein-
DG247_RS19830938617..938727-111WP_134814058.1DUF3265 domain-containing protein-
DG247_RS18750938724..939041-318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
DG247_RS18755939052..939339-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG247_RS18760939606..939786-181Protein_830DUF645 family protein-
DG247_RS18765940211..940444-234WP_032482776.1DUF3709 domain-containing protein-
DG247_RS18770940847..941065-219WP_001917086.1DUF3709 domain-containing protein-
DG247_RS18775941375..942028-654WP_000226874.1hypothetical protein-
DG247_RS18780942085..942594-510WP_000405987.1GNAT family N-acetyltransferase-
DG247_RS18785942836..943078+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG247_RS18790943097..943414+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
DG247_RS19835943608..943703-96WP_001907607.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-897525..99449796972
insideIntegroncatB9-897901..98770989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T294358 WP_001162670.1 NZ_LT992487:c939339-939052 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT294358 WP_001232701.1 NZ_LT992487:c939041-938724 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References