Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1027271..1027769 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag VCD_RS19435 Protein ID WP_000589156.1
Coordinates 1027503..1027769 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag VCD_RS19430 Protein ID WP_000643598.1
Coordinates 1027271..1027516 (-) Length 82 a.a.

Genomic Context

VCD_RS19395VCD_RS19400VCD_RS19405VCD_RS19410VCD_RS19415VCD_RS19420VCD_RS21085VCD_RS19425VCD_RS19430VCD_RS19435VCD_RS19440VCD_RS19445VCD_RS21090VCD_RS21095VCD_RS19455VCD_RS19460VCD_RS20550VCD_RS19465VCD_RS19470VCD_RS20935VCD_RS20940
Location: 1022352..1022738 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 1022895..1023401 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 1023669..1023902 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 1024175..1024534 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 1024687..1025691 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 1025907..1026089 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 1026150..1026278 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 1026381..1027175 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 1027271..1027516 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 1027503..1027769 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 1027954..1028616 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 1028744..1029211 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 1029423..1029461 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 1029515..1029658 (144 bp)
Type: Others
Protein ID: Protein_956
Location: 1030033..1030311 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 1030563..1030805 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 1030897..1031046 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 1031019..1031270 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 1031465..1031851 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 1031841..1031942 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 1032142..1032348 (207 bp)
Type: Others
Protein ID: Protein_963
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCD_RS193951022352..1022738-387WP_000703163.1VOC family protein-
VCD_RS194001022895..1023401-507WP_000393074.1hypothetical protein-
VCD_RS194051023669..1023902-234WP_001890112.1DUF3709 domain-containing protein-
VCD_RS194101024175..1024534-360WP_001071541.1VOC family protein-
VCD_RS194151024687..1025691-1005WP_000964920.1LD-carboxypeptidase-
VCD_RS194201025907..1026089-183WP_000923182.1DUF645 family protein-
VCD_RS210851026150..1026278-129WP_071908338.1general secretion pathway protein GspI-
VCD_RS194251026381..1027175-795WP_001911581.1hypothetical protein-
VCD_RS194301027271..1027516-246WP_000643598.1hypothetical proteinAntitoxin
VCD_RS194351027503..1027769-267WP_000589156.1BrnT family toxinToxin
VCD_RS194401027954..1028616-663WP_000960654.1hypothetical protein-
VCD_RS194451028744..1029211-468WP_001289288.1OsmC family protein-
VCD_RS210901029423..1029461-39WP_082798268.1hypothetical protein-
VCD_RS210951029515..1029658-144Protein_956DUF645 family protein-
VCD_RS194551030033..1030311-279WP_000280324.1DUF3709 domain-containing protein-
VCD_RS194601030563..1030805-243WP_000107461.1hypothetical protein-
VCD_RS205501030897..1031046-150WP_071908333.1DUF3265 domain-containing protein-
VCD_RS194651031019..1031270-252WP_001890111.1TIGR03643 family protein-
VCD_RS194701031465..1031851-387WP_000703163.1VOC family protein-
VCD_RS209351031841..1031942-102WP_001921603.1hypothetical protein-
VCD_RS209401032142..1032348-207Protein_963DUF3709 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932253..1057432125179
insideIntegron--958376..105059692220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T23792 WP_000589156.1 NC_012667:c1027769-1027503 [Vibrio cholerae MJ-1236]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T23792 NC_012667:c1027769-1027503 [Vibrio cholerae MJ-1236]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT23792 WP_000643598.1 NC_012667:c1027516-1027271 [Vibrio cholerae MJ-1236]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT23792 NC_012667:c1027516-1027271 [Vibrio cholerae MJ-1236]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References