23792

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1027271..1027769 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag VCD_RS19435 Protein ID WP_000589156.1
Coordinates 1027503..1027769 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag VCD_RS19430 Protein ID WP_000643598.1
Coordinates 1027271..1027516 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS19395 1022352..1022738 - 387 WP_000703163.1 VOC family protein -
VCD_RS19400 1022895..1023401 - 507 WP_000393074.1 hypothetical protein -
VCD_RS19405 1023669..1023902 - 234 WP_001890112.1 DUF3709 domain-containing protein -
VCD_RS19410 1024175..1024534 - 360 WP_001071541.1 VOC family protein -
VCD_RS19415 1024687..1025691 - 1005 WP_000964920.1 LD-carboxypeptidase -
VCD_RS19420 1025907..1026089 - 183 WP_000923182.1 DUF645 family protein -
VCD_RS21085 1026150..1026278 - 129 WP_071908338.1 general secretion pathway protein GspI -
VCD_RS19425 1026381..1027175 - 795 WP_001911581.1 hypothetical protein -
VCD_RS19430 1027271..1027516 - 246 WP_000643598.1 hypothetical protein Antitoxin
VCD_RS19435 1027503..1027769 - 267 WP_000589156.1 BrnT family toxin Toxin
VCD_RS19440 1027954..1028616 - 663 WP_000960654.1 hypothetical protein -
VCD_RS19445 1028744..1029211 - 468 WP_001289288.1 OsmC family protein -
VCD_RS21090 1029423..1029461 - 39 WP_082798268.1 hypothetical protein -
VCD_RS21095 1029515..1029658 - 144 Protein_956 DUF645 family protein -
VCD_RS19455 1030033..1030311 - 279 WP_000280324.1 DUF3709 domain-containing protein -
VCD_RS19460 1030563..1030805 - 243 WP_000107461.1 hypothetical protein -
VCD_RS20550 1030897..1031046 - 150 WP_071908333.1 DUF3265 domain-containing protein -
VCD_RS19465 1031019..1031270 - 252 WP_001890111.1 TIGR03643 family protein -
VCD_RS19470 1031465..1031851 - 387 WP_000703163.1 VOC family protein -
VCD_RS20935 1031841..1031942 - 102 WP_001921603.1 hypothetical protein -
VCD_RS20940 1032142..1032348 - 207 Protein_963 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T23792 WP_000589156.1 NC_012667:c1027769-1027503 [Vibrio cholerae MJ-1236]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T23792 NC_012667:c1027769-1027503 [Vibrio cholerae MJ-1236]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT23792 WP_000643598.1 NC_012667:c1027516-1027271 [Vibrio cholerae MJ-1236]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT23792 NC_012667:c1027516-1027271 [Vibrio cholerae MJ-1236]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References