74617

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 758676..759223 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag A6J62_RS03440 Protein ID WP_000229317.1
Coordinates 758676..758978 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag A6J62_RS03445 Protein ID WP_000861987.1
Coordinates 758966..759223 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J62_RS03400 753839..753943 - 105 WP_099607150.1 acetyltransferase -
A6J62_RS03405 754000..754599 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
A6J62_RS03410 754749..755621 - 873 WP_000254716.1 DUF3800 domain-containing protein -
A6J62_RS03415 755796..756014 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
A6J62_RS03420 756078..756515 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
A6J62_RS03425 756634..756843 - 210 Protein_647 GNAT family N-acetyltransferase -
A6J62_RS03430 756979..757368 - 390 WP_001081302.1 hypothetical protein -
A6J62_RS03435 757525..758442 - 918 WP_000186333.1 alpha/beta hydrolase -
A6J62_RS03440 758676..758978 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J62_RS03445 758966..759223 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A6J62_RS03455 759425..759958 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
A6J62_RS19635 759955..760380 - 426 WP_001882332.1 DUF1778 domain-containing protein -
A6J62_RS03465 760447..760818 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
A6J62_RS03470 760959..761246 - 288 WP_000426470.1 hypothetical protein -
A6J62_RS03475 761398..762066 - 669 WP_000043871.1 hypothetical protein -
A6J62_RS03480 762297..762569 + 273 WP_000246253.1 DUF1778 domain-containing protein -
A6J62_RS03485 762566..763063 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
A6J62_RS03495 763265..763417 - 153 WP_001884520.1 DUF645 family protein -
A6J62_RS03500 763739..764194 - 456 WP_001245327.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 749087..881909 132822
inside Integron - - 749463..875103 125640
flank IS/Tn - - 756078..756515 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T74617 WP_000229317.1 NZ_CP020407:c758978-758676 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T74617 NZ_CP020407:c758978-758676 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT74617 WP_000861987.1 NZ_CP020407:c759223-758966 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT74617 NZ_CP020407:c759223-758966 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References