Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 758676..759223 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag A6J62_RS03440 Protein ID WP_000229317.1
Coordinates 758676..758978 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag A6J62_RS03445 Protein ID WP_000861987.1
Coordinates 758966..759223 (-) Length 86 a.a.

Genomic Context

A6J62_RS03480A6J62_RS03485A6J62_RS03400A6J62_RS03405A6J62_RS03410A6J62_RS03415A6J62_RS03420A6J62_RS03425A6J62_RS03430A6J62_RS03435A6J62_RS03440A6J62_RS03445A6J62_RS03455A6J62_RS19635A6J62_RS03465A6J62_RS03470A6J62_RS03475A6J62_RS03495A6J62_RS03500
Location: 762297..762569 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 762566..763063 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 753839..753943 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 754000..754599 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 754749..755621 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 755796..756014 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 756078..756515 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 756634..756843 (210 bp)
Type: Others
Protein ID: Protein_647
Location: 756979..757368 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 757525..758442 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 758676..758978 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 758966..759223 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 759425..759958 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 759955..760380 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 760447..760818 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 760959..761246 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 761398..762066 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 763265..763417 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 763739..764194 (456 bp)
Type: Others
Protein ID: WP_001245327.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A6J62_RS03400753839..753943-105WP_099607150.1acetyltransferase-
A6J62_RS03405754000..754599-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
A6J62_RS03410754749..755621-873WP_000254716.1DUF3800 domain-containing protein-
A6J62_RS03415755796..756014-219WP_071908318.1GNAT family N-acetyltransferase-
A6J62_RS03420756078..756515-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
A6J62_RS03425756634..756843-210Protein_647GNAT family N-acetyltransferase-
A6J62_RS03430756979..757368-390WP_001081302.1hypothetical protein-
A6J62_RS03435757525..758442-918WP_000186333.1alpha/beta hydrolase-
A6J62_RS03440758676..758978-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A6J62_RS03445758966..759223-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
A6J62_RS03455759425..759958-534WP_000118351.1GNAT family N-acetyltransferase-
A6J62_RS19635759955..760380-426WP_001882332.1DUF1778 domain-containing protein-
A6J62_RS03465760447..760818-372WP_001164080.1nucleotide pyrophosphohydrolase-
A6J62_RS03470760959..761246-288WP_000426470.1hypothetical protein-
A6J62_RS03475761398..762066-669WP_000043871.1hypothetical protein-
A6J62_RS03480762297..762569+273WP_000246253.1DUF1778 domain-containing protein-
A6J62_RS03485762566..763063+498WP_000982260.1GNAT family N-acetyltransferase-
A6J62_RS03495763265..763417-153WP_001884520.1DUF645 family protein-
A6J62_RS03500763739..764194-456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-749087..881909132822
insideIntegron--749463..875103125640
flankIS/Tn--756078..756515437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T74617 WP_000229317.1 NZ_CP020407:c758978-758676 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T74617 NZ_CP020407:c758978-758676 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT74617 WP_000861987.1 NZ_CP020407:c759223-758966 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT74617 NZ_CP020407:c759223-758966 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References