Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 917706..918339 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag DG247_RS18530 Protein ID WP_000843587.1
Coordinates 918007..918339 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DG247_RS18525 Protein ID WP_000071008.1
Coordinates 917706..918020 (-) Length 105 a.a.

Genomic Context

DG247_RS18515DG247_RS18480DG247_RS18485DG247_RS18490DG247_RS18495DG247_RS18500DG247_RS18505DG247_RS18510DG247_RS19670DG247_RS18520DG247_RS18525DG247_RS18530DG247_RS18540DG247_RS19800DG247_RS18560DG247_RS19805DG247_RS18565DG247_RS18570DG247_RS18575DG247_RS19870DG247_RS18585DG247_RS18590DG247_RS19725
Location: 915707..916687 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 912760..913047 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 913037..913288 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 913502..913915 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 913990..914133 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 914103..914504 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 914504..915196 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 915333..915639 (307 bp)
Type: Others
Protein ID: Protein_787
Location: 916812..916967 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 917135..917569 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 917706..918020 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 918007..918339 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 918680..918907 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 918856..918969 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 919135..919416 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 919365..919479 (115 bp)
Type: Others
Protein ID: Protein_796
Location: 919536..919913 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 920084..920326 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 920528..920914 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 921123..921294 (172 bp)
Type: Others
Protein ID: Protein_800
Location: 921612..921881 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 922241..922414 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 922695..922898 (204 bp)
Type: Others
Protein ID: WP_001911745.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG247_RS18480912760..913047-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
DG247_RS18485913037..913288-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG247_RS18490913502..913915-414WP_000049417.1VOC family protein-
DG247_RS18495913990..914133-144WP_071908341.1DUF3265 domain-containing protein-
DG247_RS18500914103..914504-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
DG247_RS18505914504..915196-693WP_001047169.1GNAT family N-acetyltransferase-
DG247_RS18510915333..915639-307Protein_787CatB-related O-acetyltransferase-
DG247_RS18515915707..916687+981WP_000019370.1IS5-like element ISVch5 family transposase-
DG247_RS19670916812..916967-156WP_000751734.1hypothetical protein-
DG247_RS18520917135..917569-435WP_000256036.1GNAT family N-acetyltransferase-
DG247_RS18525917706..918020-315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
DG247_RS18530918007..918339-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG247_RS18540918680..918907-228WP_001894457.1DUF1289 domain-containing protein-
DG247_RS19800918856..918969-114WP_001889158.1hypothetical protein-
DG247_RS18560919135..919416-282WP_001894453.1DUF1289 domain-containing protein-
DG247_RS19805919365..919479-115Protein_796acetyltransferase-
DG247_RS18565919536..919913-378WP_000411109.1hypothetical protein-
DG247_RS18570920084..920326-243WP_000107461.1hypothetical protein-
DG247_RS18575920528..920914-387WP_000703163.1VOC family protein-
DG247_RS19870921123..921294-172Protein_800DUF645 family protein-
DG247_RS18585921612..921881-270WP_001198131.1hypothetical protein-
DG247_RS18590922241..922414-174WP_001882305.1DUF3709 domain-containing protein-
DG247_RS19725922695..922898-204WP_001911745.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-897525..99449796972
insideIntegroncatB9-897901..98770989808
flankIS/Tn--915707..916687980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T294356 WP_000843587.1 NZ_LT992487:c918339-918007 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT294356 WP_000071008.1 NZ_LT992487:c918020-917706 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References