294356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 917706..918339 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag DG247_RS18530 Protein ID WP_000843587.1
Coordinates 918007..918339 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DG247_RS18525 Protein ID WP_000071008.1
Coordinates 917706..918020 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG247_RS18480 912760..913047 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
DG247_RS18485 913037..913288 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DG247_RS18490 913502..913915 - 414 WP_000049417.1 VOC family protein -
DG247_RS18495 913990..914133 - 144 WP_071908341.1 DUF3265 domain-containing protein -
DG247_RS18500 914103..914504 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
DG247_RS18505 914504..915196 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
DG247_RS18510 915333..915639 - 307 Protein_787 CatB-related O-acetyltransferase -
DG247_RS18515 915707..916687 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
DG247_RS19670 916812..916967 - 156 WP_000751734.1 hypothetical protein -
DG247_RS18520 917135..917569 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
DG247_RS18525 917706..918020 - 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
DG247_RS18530 918007..918339 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DG247_RS18540 918680..918907 - 228 WP_001894457.1 DUF1289 domain-containing protein -
DG247_RS19800 918856..918969 - 114 WP_001889158.1 hypothetical protein -
DG247_RS18560 919135..919416 - 282 WP_001894453.1 DUF1289 domain-containing protein -
DG247_RS19805 919365..919479 - 115 Protein_796 acetyltransferase -
DG247_RS18565 919536..919913 - 378 WP_000411109.1 hypothetical protein -
DG247_RS18570 920084..920326 - 243 WP_000107461.1 hypothetical protein -
DG247_RS18575 920528..920914 - 387 WP_000703163.1 VOC family protein -
DG247_RS19870 921123..921294 - 172 Protein_800 DUF645 family protein -
DG247_RS18585 921612..921881 - 270 WP_001198131.1 hypothetical protein -
DG247_RS18590 922241..922414 - 174 WP_001882305.1 DUF3709 domain-containing protein -
DG247_RS19725 922695..922898 - 204 WP_001911745.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 897525..994497 96972
inside Integron catB9 - 897901..987709 89808
flank IS/Tn - - 915707..916687 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T294356 WP_000843587.1 NZ_LT992487:c918339-918007 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT294356 WP_000071008.1 NZ_LT992487:c918020-917706 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References