104255

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 401605..402133 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag N16961_RS16345 Protein ID WP_000221352.1
Coordinates 401605..401895 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag N16961_RS16350 Protein ID WP_000213183.1
Coordinates 401885..402133 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N16961_RS19930 397162..397287 + 126 WP_001944767.1 DUF645 family protein -
N16961_RS19935 397303..397341 + 39 WP_106019119.1 hypothetical protein -
N16961_RS16315 397554..398558 + 1005 WP_000964925.1 LD-carboxypeptidase -
N16961_RS16320 398711..399157 + 447 WP_000128977.1 hypothetical protein -
N16961_RS16325 399277..400206 + 930 WP_000335802.1 hypothetical protein -
N16961_RS16330 400203..400313 + 111 WP_071917832.1 DUF3265 domain-containing protein -
N16961_RS16335 400341..400817 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
N16961_RS16340 400954..401469 + 516 WP_001201528.1 lipocalin family protein -
N16961_RS16345 401605..401895 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N16961_RS16350 401885..402133 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N16961_RS16365 402704..403357 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
N16961_RS16370 403629..404054 + 426 WP_000415748.1 hypothetical protein -
N16961_RS16375 404262..404657 + 396 WP_000649527.1 DUF3465 domain-containing protein -
N16961_RS16380 404808..405338 + 531 WP_000415563.1 hypothetical protein -
N16961_RS16385 405476..405976 + 501 WP_000789723.1 hypothetical protein -
N16961_RS16395 406132..406530 + 399 WP_001882293.1 hypothetical protein -
N16961_RS16400 406630..407094 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306977..438073 131096
inside Integron - - 312057..437697 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T104255 WP_000221352.1 NZ_CP028828:c401895-401605 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T104255 NZ_CP028828:c401895-401605 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT104255 WP_000213183.1 NZ_CP028828:c402133-401885 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT104255 NZ_CP028828:c402133-401885 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References