Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 369423..370038 Replicon chromosome
Accession NZ_LT906615
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag FY484_RS15865 Protein ID WP_001162670.1
Coordinates 369423..369710 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FY484_RS15870 Protein ID WP_001232701.1
Coordinates 369721..370038 (+) Length 106 a.a.

Genomic Context

FY484_RS19515FY484_RS15840FY484_RS15845FY484_RS15850FY484_RS15855FY484_RS15860FY484_RS15865FY484_RS15870FY484_RS19520FY484_RS15885FY484_RS15890FY484_RS15895FY484_RS15900FY484_RS15905FY484_RS15915FY484_RS15920FY484_RS15830FY484_RS15835
Location: 365059..365154 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 366168..366677 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 366734..367387 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 367697..367915 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 368318..368551 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 368976..369156 (181 bp)
Type: Others
Protein ID: Protein_363
Location: 369423..369710 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 369721..370038 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 370035..370145 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 370322..370447 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 370463..370501 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 370725..371465 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 371670..372500 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 372557..373039 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 373486..374361 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 374491..374946 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 365348..365665 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 365684..365926 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FY484_RS19515365059..365154+96WP_001907607.1DUF645 family protein-
FY484_RS15830365348..365665-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
FY484_RS15835365684..365926-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FY484_RS15840366168..366677+510WP_000405987.1GNAT family N-acetyltransferase-
FY484_RS15845366734..367387+654WP_000226874.1hypothetical protein-
FY484_RS15850367697..367915+219WP_001917086.1DUF3709 domain-containing protein-
FY484_RS15855368318..368551+234WP_032482776.1DUF3709 domain-containing protein-
FY484_RS15860368976..369156+181Protein_363DUF645 family protein-
FY484_RS15865369423..369710+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FY484_RS15870369721..370038+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
FY484_RS19520370035..370145+111WP_134814058.1DUF3265 domain-containing protein-
FY484_RS15885370322..370447+126WP_001944767.1DUF645 family protein-
FY484_RS15890370463..370501+39WP_106019119.1hypothetical protein-
FY484_RS15895370725..371465+741WP_000469836.1PhzF family phenazine biosynthesis protein-
FY484_RS15900371670..372500+831WP_000056616.1abortive infection family protein-
FY484_RS15905372557..373039+483WP_001895003.1hypothetical protein-
FY484_RS15915373486..374361+876WP_000259044.1hypothetical protein-
FY484_RS15920374491..374946+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T293799 WP_001162670.1 NZ_LT906615:369423-369710 [Vibrio cholerae O1 biovar El Tor str. N16961]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT293799 WP_001232701.1 NZ_LT906615:369721-370038 [Vibrio cholerae O1 biovar El Tor str. N16961]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References