Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 393488..394581 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GQX72_RS15880 Protein ID WP_000351248.1
Coordinates 394180..394581 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GQX72_RS15875 Protein ID WP_001047169.1
Coordinates 393488..394180 (+) Length 231 a.a.

Genomic Context

GQX72_RS15815GQX72_RS19050GQX72_RS15820GQX72_RS15830GQX72_RS15835GQX72_RS15845GQX72_RS15850GQX72_RS15855GQX72_RS15860GQX72_RS15870GQX72_RS15875GQX72_RS15880GQX72_RS15885GQX72_RS15890GQX72_RS15895GQX72_RS15900GQX72_RS15905GQX72_RS15910GQX72_RS15930GQX72_RS15935GQX72_RS15865GQX72_RS15920GQX72_RS15925
Location: 388771..389148 (378 bp)
Type: Others
Protein ID: WP_000411106.1
Location: 389205..389319 (115 bp)
Type: Others
Protein ID: Protein_395
Location: 389268..389549 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 389715..389828 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 389777..390004 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 390345..390677 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 390664..390978 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 391115..391549 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 391717..391872 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 393045..393351 (307 bp)
Type: Others
Protein ID: Protein_404
Location: 393488..394180 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 394180..394581 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 394551..394694 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 394769..395182 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 395396..395647 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 395637..395924 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 396052..396507 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 396829..396981 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 398180..398848 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 399000..399287 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 391997..392977 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 397183..397680 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 397677..397949 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQX72_RS15815388771..389148+378WP_000411106.1hypothetical protein-
GQX72_RS19050389205..389319+115Protein_395acetyltransferase-
GQX72_RS15820389268..389549+282WP_001894453.1DUF1289 domain-containing protein-
GQX72_RS15830389715..389828+114WP_001889158.1hypothetical protein-
GQX72_RS15835389777..390004+228WP_001894457.1DUF1289 domain-containing protein-
GQX72_RS15845390345..390677+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
GQX72_RS15850390664..390978+315WP_000071008.1DNA-binding transcriptional regulator-
GQX72_RS15855391115..391549+435WP_000256036.1GNAT family N-acetyltransferase-
GQX72_RS15860391717..391872+156WP_000751734.1hypothetical protein-
GQX72_RS15865391997..392977-981WP_000019370.1IS5-like element ISVch5 family transposase-
GQX72_RS15870393045..393351+307Protein_404CatB-related O-acetyltransferase-
GQX72_RS15875393488..394180+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
GQX72_RS15880394180..394581+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
GQX72_RS15885394551..394694+144WP_071908341.1DUF3265 domain-containing protein-
GQX72_RS15890394769..395182+414WP_000049417.1VOC family protein-
GQX72_RS15895395396..395647+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GQX72_RS15900395637..395924+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GQX72_RS15905396052..396507+456WP_001245327.1GNAT family N-acetyltransferase-
GQX72_RS15910396829..396981+153WP_001884520.1DUF645 family protein-
GQX72_RS15920397183..397680-498WP_000982260.1GNAT family N-acetyltransferase-
GQX72_RS15925397677..397949-273WP_000246253.1DUF1778 domain-containing protein-
GQX72_RS15930398180..398848+669WP_000043871.1hypothetical protein-
GQX72_RS15935399000..399287+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305960..411159105199
insideIntegron--311040..41078399743
flankIS/Tn--391997..392977980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T145402 WP_000351248.1 NZ_CP047060:394180-394581 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T145402 NZ_CP062376:2271772-2272038 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT145402 WP_001047169.1 NZ_CP047060:393488-394180 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT145402 NZ_CP062376:2271515-2271772 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References