Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 50881..51647 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag EN18_RS14405 Protein ID WP_000982260.1
Coordinates 50881..51378 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag EN18_RS14410 Protein ID WP_000246253.1
Coordinates 51375..51647 (-) Length 91 a.a.

Genomic Context

EN18_RS14360EN18_RS14365EN18_RS14380EN18_RS20495EN18_RS14385EN18_RS14395EN18_RS14400EN18_RS21085EN18_RS21090EN18_RS14425EN18_RS14430EN18_RS20510EN18_RS21105EN18_RS21110EN18_RS14450EN18_RS14370EN18_RS14375EN18_RS14405EN18_RS14410EN18_RS14435EN18_RS14440
Location: 46323..47027 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 47185..47523 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 48499..48885 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 48942..49055 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 49004..49285 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 49543..50079 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 50216..50731 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 52040..52165 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 52181..52219 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 52415..52861 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 52924..54135 (1212 bp)
Type: Others
Protein ID: WP_001122813.1
Location: 55148..55426 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 55678..55884 (207 bp)
Type: Others
Protein ID: Protein_69
Location: 56084..56185 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 56175..56561 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 47677..47994 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 48013..48255 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 50881..51378 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 51375..51647 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 54322..54591 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 54584..54862 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS1436046323..47027+705WP_000087610.1HNH endonuclease-
EN18_RS1436547185..47523+339WP_000713853.1hypothetical protein-
EN18_RS1437047677..47994-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
EN18_RS1437548013..48255-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
EN18_RS1438048499..48885+387WP_001015867.1NUDIX hydrolase-
EN18_RS2049548942..49055+114WP_001900214.1hypothetical protein-
EN18_RS1438549004..49285+282WP_001894429.1DUF1289 domain-containing protein-
EN18_RS1439549543..50079+537WP_000469482.1GNAT family N-acetyltransferase-
EN18_RS1440050216..50731+516WP_001201509.1lipocalin family protein-
EN18_RS1440550881..51378-498WP_000982260.1GNAT family N-acetyltransferaseToxin
EN18_RS1441051375..51647-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
EN18_RS2108552040..52165+126WP_001900195.1DUF645 family protein-
EN18_RS2109052181..52219+39WP_106019118.1hypothetical protein-
EN18_RS1442552415..52861+447WP_000006157.1hypothetical protein-
EN18_RS1443052924..54135+1212WP_001122813.1IS256 family transposase-
EN18_RS1443554322..54591-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
EN18_RS1444054584..54862-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
EN18_RS2051055148..55426+279WP_001921601.1DUF3709 domain-containing protein-
EN18_RS2110555678..55884+207Protein_69DUF3709 domain-containing protein-
EN18_RS2111056084..56185+102WP_001921603.1hypothetical protein-
EN18_RS1445056175..56561+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049
-flankIS/Tn--52924..541351211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T46750 WP_000982260.1 NZ_CP007635:c51378-50881 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T46750 NZ_CP007635:c51378-50881 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT46750 WP_000246253.1 NZ_CP007635:c51647-51375 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT46750 NZ_CP007635:c51647-51375 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References