145071

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 396706..397472 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GPY07_RS16450 Protein ID WP_000982260.1
Coordinates 396975..397472 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GPY07_RS16445 Protein ID WP_000246253.1
Coordinates 396706..396978 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS16380 392203..392445 - 243 WP_000107461.1 hypothetical protein -
GPY07_RS16385 392537..392686 - 150 WP_071908333.1 DUF3265 domain-containing protein -
GPY07_RS16390 392659..392910 - 252 WP_001890111.1 TIGR03643 family protein -
GPY07_RS16395 393105..393491 - 387 WP_000703163.1 VOC family protein -
GPY07_RS16400 393481..393582 - 102 WP_001921603.1 hypothetical protein -
GPY07_RS16405 393782..393988 - 207 Protein_407 DUF3709 domain-containing protein -
GPY07_RS16410 394240..394518 - 279 WP_001921601.1 DUF3709 domain-containing protein -
GPY07_RS16415 394804..395082 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GPY07_RS16420 395075..395344 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
GPY07_RS16425 395492..395938 - 447 WP_000006157.1 hypothetical protein -
GPY07_RS16435 396134..396172 - 39 WP_106019118.1 hypothetical protein -
GPY07_RS16440 396188..396313 - 126 WP_001900195.1 DUF645 family protein -
GPY07_RS16445 396706..396978 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
GPY07_RS16450 396975..397472 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GPY07_RS16455 397622..398137 - 516 WP_001201509.1 lipocalin family protein -
GPY07_RS16460 398274..398810 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
GPY07_RS16470 399068..399349 - 282 WP_001894429.1 DUF1289 domain-containing protein -
GPY07_RS16475 399298..399411 - 114 WP_001900214.1 hypothetical protein -
GPY07_RS16480 399468..399854 - 387 WP_001015867.1 NUDIX hydrolase -
GPY07_RS16485 400098..400340 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPY07_RS16490 400359..400676 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPY07_RS16500 400830..401168 - 339 WP_000713853.1 hypothetical protein -
GPY07_RS16505 401326..402030 - 705 WP_000087610.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145071 WP_000982260.1 NZ_CP046841:396975-397472 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145071 NZ_CP062253:3712111-3712395 [Pseudomonas gozinkensis]
CTGCCGCTTGAATGGAGCGATCAAGCTCTGGACGATCTGGCTGACATTATCGATTACATTGAACAATACAACTCAAACGC
TTCAACGGCTCTGCAGCACAAGGTGGGTGCAGCAACGCAAAGGCTTTCATCAATCCCCTATGGTTACCGGTCCGGTCGAG
CGCCAGGCACTCGGGAAATGGTGGTCAATCCGAACTATCTGCTGGTCTATCGAGTGAACGGGCGCATCAAAATACTGACG
TTAGTCCACACCCGACGACAATACCCACGAACCTCATCACCATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145071 WP_000246253.1 NZ_CP046841:396706-396978 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145071 NZ_CP062253:3711927-3712121 [Pseudomonas gozinkensis]
ATGAGCTTATTACTTTCCCCGTTTTACTCTGACTTCGAATCCGAAGAAGAGGCCGAGAGCTACGATCGCTGGTTTCGTGC
CAAGGTGCAGGCTGTACTGGATGATCCTCGCCCGGGCATTCCCCATGAGGAAGCCATGGTGCGGCTCGACCAGTTATTAG
AAGAGAGACGCAAGAATCGACGCGCTGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References