Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 121779..122307 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag EN18_RS14955 Protein ID WP_000221354.1
Coordinates 122020..122307 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag EN18_RS14950 Protein ID WP_001250179.1
Coordinates 121779..122030 (+) Length 84 a.a.

Genomic Context

EN18_RS14910EN18_RS14915EN18_RS21395EN18_RS14930EN18_RS14935EN18_RS14940EN18_RS21220EN18_RS14945EN18_RS14950EN18_RS14955EN18_RS14960EN18_RS14965EN18_RS14980EN18_RS14985EN18_RS14990EN18_RS14995EN18_RS15000EN18_RS14925EN18_RS14970EN18_RS14975
Location: 117047..117361 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 117498..117932 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 118100..118255 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 119428..119734 (307 bp)
Type: Others
Protein ID: Protein_183
Location: 119871..120563 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 120563..120964 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 120934..121077 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 121152..121565 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 121779..122030 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 122020..122307 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 122435..122890 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 123212..123364 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 124563..125231 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 125383..125670 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 125811..126182 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 126249..126674 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 126671..127204 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 118380..119360 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 123566..124063 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 124060..124332 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS14910117047..117361+315WP_000071008.1DNA-binding transcriptional regulator-
EN18_RS14915117498..117932+435WP_000256036.1GNAT family N-acetyltransferase-
EN18_RS21395118100..118255+156WP_000751734.1hypothetical protein-
EN18_RS14925118380..119360-981WP_000019370.1IS5-like element ISVch5 family transposase-
EN18_RS14930119428..119734+307Protein_183CatB-related O-acetyltransferase-
EN18_RS14935119871..120563+693WP_001047169.1GNAT family N-acetyltransferase-
EN18_RS14940120563..120964+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
EN18_RS21220120934..121077+144WP_071908341.1DUF3265 domain-containing protein-
EN18_RS14945121152..121565+414WP_000049417.1VOC family protein-
EN18_RS14950121779..122030+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
EN18_RS14955122020..122307+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EN18_RS14960122435..122890+456WP_001245327.1GNAT family N-acetyltransferase-
EN18_RS14965123212..123364+153WP_001884520.1DUF645 family protein-
EN18_RS14970123566..124063-498WP_000982260.1GNAT family N-acetyltransferase-
EN18_RS14975124060..124332-273WP_000246253.1DUF1778 domain-containing protein-
EN18_RS14980124563..125231+669WP_000043871.1hypothetical protein-
EN18_RS14985125383..125670+288WP_000426470.1hypothetical protein-
EN18_RS14990125811..126182+372WP_001164080.1nucleotide pyrophosphohydrolase-
EN18_RS14995126249..126674+426WP_001882332.1DUF1778 domain-containing protein-
EN18_RS15000126671..127204+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049
flankIS/Tn--118380..119360980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T46760 WP_000221354.1 NZ_CP007635:122020-122307 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T46760 NZ_CP007635:122020-122307 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT46760 WP_001250179.1 NZ_CP007635:121779-122030 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT46760 NZ_CP007635:121779-122030 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References