46760

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 121779..122307 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag EN18_RS14955 Protein ID WP_000221354.1
Coordinates 122020..122307 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag EN18_RS14950 Protein ID WP_001250179.1
Coordinates 121779..122030 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EN18_RS14910 117047..117361 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
EN18_RS14915 117498..117932 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
EN18_RS21395 118100..118255 + 156 WP_000751734.1 hypothetical protein -
EN18_RS14925 118380..119360 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
EN18_RS14930 119428..119734 + 307 Protein_183 CatB-related O-acetyltransferase -
EN18_RS14935 119871..120563 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
EN18_RS14940 120563..120964 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
EN18_RS21220 120934..121077 + 144 WP_071908341.1 DUF3265 domain-containing protein -
EN18_RS14945 121152..121565 + 414 WP_000049417.1 VOC family protein -
EN18_RS14950 121779..122030 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EN18_RS14955 122020..122307 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EN18_RS14960 122435..122890 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
EN18_RS14965 123212..123364 + 153 WP_001884520.1 DUF645 family protein -
EN18_RS14970 123566..124063 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
EN18_RS14975 124060..124332 - 273 WP_000246253.1 DUF1778 domain-containing protein -
EN18_RS14980 124563..125231 + 669 WP_000043871.1 hypothetical protein -
EN18_RS14985 125383..125670 + 288 WP_000426470.1 hypothetical protein -
EN18_RS14990 125811..126182 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
EN18_RS14995 126249..126674 + 426 WP_001882332.1 DUF1778 domain-containing protein -
EN18_RS15000 126671..127204 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31037..137542 106505
inside Integron - - 36117..137166 101049
flank IS/Tn - - 118380..119360 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T46760 WP_000221354.1 NZ_CP007635:122020-122307 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T46760 NZ_CP007635:122020-122307 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT46760 WP_001250179.1 NZ_CP007635:121779-122030 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT46760 NZ_CP007635:121779-122030 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References