180882

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 499736..500295 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag IT766_RS16395 Protein ID WP_000578476.1
Coordinates 499736..500014 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag IT766_RS16400 Protein ID WP_000381183.1
Coordinates 500011..500295 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS16350 495036..495473 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
IT766_RS16355 495537..495755 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
IT766_RS16360 495930..496802 + 873 WP_000254716.1 DUF3800 domain-containing protein -
IT766_RS16365 496952..497551 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
IT766_RS16370 497608..497712 + 105 WP_099607150.1 acetyltransferase -
IT766_RS16375 497743..498012 + 270 WP_001114075.1 DUF4160 domain-containing protein -
IT766_RS16380 498006..498527 + 522 WP_000921691.1 DUF2442 domain-containing protein -
IT766_RS16385 498826..498951 + 126 WP_001905700.1 DUF645 family protein -
IT766_RS16390 499202..499597 + 396 WP_001000867.1 hypothetical protein -
IT766_RS16395 499736..500014 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
IT766_RS16400 500011..500295 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IT766_RS16405 500489..501004 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
IT766_RS16410 501188..501601 + 414 WP_000049420.1 VOC family protein -
IT766_RS16415 502156..503333 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804
flank IS/Tn - - 495036..495473 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T180882 WP_000578476.1 NZ_CP064351:c500014-499736 [Vibrio cholerae C6706]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T180882 NZ_CP085771:42096-42383 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT180882 WP_000381183.1 NZ_CP064351:c500295-500011 [Vibrio cholerae C6706]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT180882 NZ_CP085771:41857-42096 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References