Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 356303..356881 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag KAF59_RS15550 Protein ID WP_001180243.1
Coordinates 356303..356620 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag KAF59_RS15555 Protein ID WP_000557292.1
Coordinates 356639..356881 (-) Length 81 a.a.

Genomic Context

KAF59_RS15505KAF59_RS18845KAF59_RS15510KAF59_RS15515KAF59_RS15520KAF59_RS18850KAF59_RS18855KAF59_RS15530KAF59_RS15535KAF59_RS15540KAF59_RS18860KAF59_RS18865KAF59_RS15560KAF59_RS15565KAF59_RS18870KAF59_RS15570KAF59_RS18875KAF59_RS15575KAF59_RS15580KAF59_RS18880KAF59_RS15585KAF59_RS15590KAF59_RS15595KAF59_RS18885KAF59_RS15600KAF59_RS18890KAF59_RS15550KAF59_RS15555
Location: 351533..351889 (357 bp)
Type: Others
Protein ID: WP_001094969.1
Location: 351988..352131 (144 bp)
Type: Others
Protein ID: Protein_338
Location: 352254..352373 (120 bp)
Type: Others
Protein ID: WP_001900954.1
Location: 352550..352945 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 353089..353625 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 353976..354038 (63 bp)
Type: Others
Protein ID: Protein_342
Location: 354028..354138 (111 bp)
Type: Others
Protein ID: WP_223804330.1
Location: 354297..354722 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 354871..355218 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 355365..355658 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 355721..355896 (176 bp)
Type: Others
Protein ID: Protein_347
Location: 355957..356109 (153 bp)
Type: Others
Protein ID: Protein_348
Location: 357123..357632 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 357689..358342 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 358431..358640 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 358652..358870 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 359059..359252 (194 bp)
Type: Others
Protein ID: Protein_355
Location: 359273..359506 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 359931..360111 (181 bp)
Type: Others
Protein ID: Protein_357
Location: 360224..360337 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 360378..360665 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 360676..360993 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 360990..361100 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 361139..361249 (111 bp)
Type: Others
Protein ID: Protein_362
Location: 361277..361402 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 361365..361481 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 356303..356620 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 356639..356881 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KAF59_RS15505 (KAF59_15505)351533..351889+357WP_001094969.1DUF6404 family protein-
KAF59_RS18845351988..352131+144Protein_338acetyltransferase-
KAF59_RS15510 (KAF59_15510)352254..352373+120WP_001900954.1DUF645 family protein-
KAF59_RS15515 (KAF59_15515)352550..352945+396WP_000046953.1DUF6404 family protein-
KAF59_RS15520 (KAF59_15520)353089..353625+537WP_000644491.1nucleotidyltransferase family protein-
KAF59_RS18850353976..354038+63Protein_342DUF645 family protein-
KAF59_RS18855354028..354138+111WP_223804330.1Tfp pilus assembly protein-
KAF59_RS15530 (KAF59_15530)354297..354722+426WP_000403014.1GNAT family N-acetyltransferase-
KAF59_RS15535 (KAF59_15535)354871..355218+348WP_000933409.1hypothetical protein-
KAF59_RS15540 (KAF59_15540)355365..355658+294WP_125460920.1hypothetical protein-
KAF59_RS18860355721..355896+176Protein_347acetyltransferase-
KAF59_RS18865355957..356109+153Protein_348DUF645 family protein-
KAF59_RS15550 (KAF59_15550)356303..356620-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KAF59_RS15555 (KAF59_15555)356639..356881-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
KAF59_RS15560 (KAF59_15560)357123..357632+510WP_000405987.1GNAT family N-acetyltransferase-
KAF59_RS15565 (KAF59_15565)357689..358342+654WP_000226874.1hypothetical protein-
KAF59_RS18870358431..358640+210WP_001900246.1DUF3709 domain-containing protein-
KAF59_RS15570 (KAF59_15570)358652..358870+219WP_001917086.1DUF3709 domain-containing protein-
KAF59_RS18875359059..359252+194Protein_355hypothetical protein-
KAF59_RS15575 (KAF59_15575)359273..359506+234WP_032482776.1DUF3709 domain-containing protein-
KAF59_RS15580 (KAF59_15580)359931..360111+181Protein_357DUF645 family protein-
KAF59_RS18880360224..360337+114WP_001894955.1hypothetical protein-
KAF59_RS15585 (KAF59_15585)360378..360665+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
KAF59_RS15590 (KAF59_15590)360676..360993+318WP_001232701.1HigA family addiction module antitoxin-
KAF59_RS15595 (KAF59_15595)360990..361100+111WP_134814058.1DUF3265 domain-containing protein-
KAF59_RS18885361139..361249+111Protein_362acetyltransferase-
KAF59_RS15600 (KAF59_15600)361277..361402+126WP_001944767.1DUF645 family protein-
KAF59_RS18890361365..361481+117WP_001889170.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306928..40218995261
insideIntegroncatB9-312008..40181389805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T199003 WP_001180243.1 NZ_CP072850:c356620-356303 [Vibrio cholerae MO10]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T199003 NZ_CP097083:c207207-206764 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT199003 WP_000557292.1 NZ_CP072850:c356881-356639 [Vibrio cholerae MO10]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT199003 NZ_CP097083:c207434-207204 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References