199003

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 356303..356881 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag KAF59_RS15550 Protein ID WP_001180243.1
Coordinates 356303..356620 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag KAF59_RS15555 Protein ID WP_000557292.1
Coordinates 356639..356881 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS15505 (KAF59_15505) 351533..351889 + 357 WP_001094969.1 DUF6404 family protein -
KAF59_RS18845 351988..352131 + 144 Protein_338 acetyltransferase -
KAF59_RS15510 (KAF59_15510) 352254..352373 + 120 WP_001900954.1 DUF645 family protein -
KAF59_RS15515 (KAF59_15515) 352550..352945 + 396 WP_000046953.1 DUF6404 family protein -
KAF59_RS15520 (KAF59_15520) 353089..353625 + 537 WP_000644491.1 nucleotidyltransferase family protein -
KAF59_RS18850 353976..354038 + 63 Protein_342 DUF645 family protein -
KAF59_RS18855 354028..354138 + 111 WP_223804330.1 Tfp pilus assembly protein -
KAF59_RS15530 (KAF59_15530) 354297..354722 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
KAF59_RS15535 (KAF59_15535) 354871..355218 + 348 WP_000933409.1 hypothetical protein -
KAF59_RS15540 (KAF59_15540) 355365..355658 + 294 WP_125460920.1 hypothetical protein -
KAF59_RS18860 355721..355896 + 176 Protein_347 acetyltransferase -
KAF59_RS18865 355957..356109 + 153 Protein_348 DUF645 family protein -
KAF59_RS15550 (KAF59_15550) 356303..356620 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAF59_RS15555 (KAF59_15555) 356639..356881 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KAF59_RS15560 (KAF59_15560) 357123..357632 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
KAF59_RS15565 (KAF59_15565) 357689..358342 + 654 WP_000226874.1 hypothetical protein -
KAF59_RS18870 358431..358640 + 210 WP_001900246.1 DUF3709 domain-containing protein -
KAF59_RS15570 (KAF59_15570) 358652..358870 + 219 WP_001917086.1 DUF3709 domain-containing protein -
KAF59_RS18875 359059..359252 + 194 Protein_355 hypothetical protein -
KAF59_RS15575 (KAF59_15575) 359273..359506 + 234 WP_032482776.1 DUF3709 domain-containing protein -
KAF59_RS15580 (KAF59_15580) 359931..360111 + 181 Protein_357 DUF645 family protein -
KAF59_RS18880 360224..360337 + 114 WP_001894955.1 hypothetical protein -
KAF59_RS15585 (KAF59_15585) 360378..360665 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAF59_RS15590 (KAF59_15590) 360676..360993 + 318 WP_001232701.1 HigA family addiction module antitoxin -
KAF59_RS15595 (KAF59_15595) 360990..361100 + 111 WP_134814058.1 DUF3265 domain-containing protein -
KAF59_RS18885 361139..361249 + 111 Protein_362 acetyltransferase -
KAF59_RS15600 (KAF59_15600) 361277..361402 + 126 WP_001944767.1 DUF645 family protein -
KAF59_RS18890 361365..361481 + 117 WP_001889170.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T199003 WP_001180243.1 NZ_CP072850:c356620-356303 [Vibrio cholerae MO10]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T199003 NZ_CP097083:c207207-206764 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT199003 WP_000557292.1 NZ_CP072850:c356881-356639 [Vibrio cholerae MO10]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT199003 NZ_CP097083:c207434-207204 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References