25716

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 120541..121069 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag HJ37_RS14805 Protein ID WP_000221354.1
Coordinates 120782..121069 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag HJ37_RS14800 Protein ID WP_001250179.1
Coordinates 120541..120792 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ37_RS14760 115809..116123 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
HJ37_RS14765 116260..116694 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
HJ37_RS20240 116862..117017 + 156 WP_000751734.1 hypothetical protein -
HJ37_RS14775 117142..118122 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
HJ37_RS14780 118190..118462 + 273 Protein_182 CatB-related O-acetyltransferase -
HJ37_RS14785 118633..119325 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
HJ37_RS14790 119325..119726 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
HJ37_RS20025 119696..119839 + 144 WP_071908341.1 DUF3265 domain-containing protein -
HJ37_RS14795 119914..120327 + 414 WP_000049417.1 VOC family protein -
HJ37_RS14800 120541..120792 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HJ37_RS14805 120782..121069 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HJ37_RS14810 121197..121652 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
HJ37_RS14815 121974..122126 + 153 WP_001884520.1 DUF645 family protein -
HJ37_RS14820 122328..122825 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
HJ37_RS14825 122822..123094 - 273 WP_000246253.1 DUF1778 domain-containing protein -
HJ37_RS14830 123325..123993 + 669 WP_000043871.1 hypothetical protein -
HJ37_RS14835 124145..124432 + 288 WP_000426470.1 hypothetical protein -
HJ37_RS14840 124573..124944 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
HJ37_RS20245 125011..125436 + 426 WP_001882332.1 DUF1778 domain-containing protein -
HJ37_RS14850 125433..125966 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31115..136304 105189
inside Integron catB9 - 36195..135928 99733
flank IS/Tn - - 117142..118122 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T25716 WP_000221354.1 NC_016446:120782-121069 [Vibrio cholerae O1 str. 2010EL-1786]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T25716 NC_016446:120782-121069 [Vibrio cholerae O1 str. 2010EL-1786]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT25716 WP_001250179.1 NC_016446:120541-120792 [Vibrio cholerae O1 str. 2010EL-1786]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT25716 NC_016446:120541-120792 [Vibrio cholerae O1 str. 2010EL-1786]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References