Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 99766..100294 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag C4E16_RS14955 Protein ID WP_000221352.1
Coordinates 99766..100056 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag C4E16_RS14960 Protein ID WP_000213183.1
Coordinates 100046..100294 (-) Length 83 a.a.

Genomic Context

C4E16_RS19570C4E16_RS14915C4E16_RS19440C4E16_RS14925C4E16_RS14930C4E16_RS14935C4E16_RS14940C4E16_RS14945C4E16_RS14950C4E16_RS14975C4E16_RS14980C4E16_RS14985C4E16_RS14990C4E16_RS14995C4E16_RS15005C4E16_RS14955C4E16_RS14960C4E16_RS15010
Location: 95036..95146 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 95323..95448 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 95464..95502 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 95715..96719 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 96872..97318 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 97438..98367 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 98364..98474 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 98502..98978 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 99115..99630 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 100865..101518 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 101790..102215 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 102423..102818 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 102969..103499 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 103637..104137 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 104293..104691 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 99766..100056 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 100046..100294 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 104791..105255 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS1957095036..95146+111WP_134814058.1DUF3265 domain-containing protein-
C4E16_RS1491595323..95448+126WP_001944767.1DUF645 family protein-
C4E16_RS1944095464..95502+39WP_106019119.1hypothetical protein-
C4E16_RS1492595715..96719+1005WP_000964925.1LD-carboxypeptidase-
C4E16_RS1493096872..97318+447WP_000128977.1hypothetical protein-
C4E16_RS1493597438..98367+930WP_000335802.1hypothetical protein-
C4E16_RS1494098364..98474+111WP_071917832.1DUF3265 domain-containing protein-
C4E16_RS1494598502..98978+477WP_001047180.1GNAT family N-acetyltransferase-
C4E16_RS1495099115..99630+516WP_001201528.1lipocalin family protein-
C4E16_RS1495599766..100056-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C4E16_RS14960100046..100294-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
C4E16_RS14975100865..101518+654WP_000036957.1site-specific DNA-methyltransferase-
C4E16_RS14980101790..102215+426WP_000415748.1hypothetical protein-
C4E16_RS14985102423..102818+396WP_000649527.1DUF3465 domain-containing protein-
C4E16_RS14990102969..103499+531WP_000415563.1hypothetical protein-
C4E16_RS14995103637..104137+501WP_000789723.1hypothetical protein-
C4E16_RS15005104293..104691+399WP_001882293.1hypothetical protein-
C4E16_RS15010104791..105255-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T95383 WP_000221352.1 NZ_CP026648:c100056-99766 [Vibrio cholerae O1 biovar El Tor]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T95383 NZ_CP026648:c100056-99766 [Vibrio cholerae O1 biovar El Tor]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT95383 WP_000213183.1 NZ_CP026648:c100294-100046 [Vibrio cholerae O1 biovar El Tor]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT95383 NZ_CP026648:c100294-100046 [Vibrio cholerae O1 biovar El Tor]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References