95383

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 99766..100294 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag C4E16_RS14955 Protein ID WP_000221352.1
Coordinates 99766..100056 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag C4E16_RS14960 Protein ID WP_000213183.1
Coordinates 100046..100294 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E16_RS19570 95036..95146 + 111 WP_134814058.1 DUF3265 domain-containing protein -
C4E16_RS14915 95323..95448 + 126 WP_001944767.1 DUF645 family protein -
C4E16_RS19440 95464..95502 + 39 WP_106019119.1 hypothetical protein -
C4E16_RS14925 95715..96719 + 1005 WP_000964925.1 LD-carboxypeptidase -
C4E16_RS14930 96872..97318 + 447 WP_000128977.1 hypothetical protein -
C4E16_RS14935 97438..98367 + 930 WP_000335802.1 hypothetical protein -
C4E16_RS14940 98364..98474 + 111 WP_071917832.1 DUF3265 domain-containing protein -
C4E16_RS14945 98502..98978 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
C4E16_RS14950 99115..99630 + 516 WP_001201528.1 lipocalin family protein -
C4E16_RS14955 99766..100056 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4E16_RS14960 100046..100294 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C4E16_RS14975 100865..101518 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
C4E16_RS14980 101790..102215 + 426 WP_000415748.1 hypothetical protein -
C4E16_RS14985 102423..102818 + 396 WP_000649527.1 DUF3465 domain-containing protein -
C4E16_RS14990 102969..103499 + 531 WP_000415563.1 hypothetical protein -
C4E16_RS14995 103637..104137 + 501 WP_000789723.1 hypothetical protein -
C4E16_RS15005 104293..104691 + 399 WP_001882293.1 hypothetical protein -
C4E16_RS15010 104791..105255 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31043..136234 105191
inside Integron - - 36123..135858 99735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T95383 WP_000221352.1 NZ_CP026648:c100056-99766 [Vibrio cholerae O1 biovar El Tor]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T95383 NZ_CP026648:c100056-99766 [Vibrio cholerae O1 biovar El Tor]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT95383 WP_000213183.1 NZ_CP026648:c100294-100046 [Vibrio cholerae O1 biovar El Tor]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT95383 NZ_CP026648:c100294-100046 [Vibrio cholerae O1 biovar El Tor]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References