199001

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 334835..335333 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag KAF59_RS15365 Protein ID WP_000589156.1
Coordinates 334835..335101 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag KAF59_RS15370 Protein ID WP_000643598.1
Coordinates 335088..335333 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS18810 330364..330462 + 99 WP_223225486.1 DUF3709 domain-containing protein -
KAF59_RS15315 (KAF59_15315) 330662..330763 + 102 WP_001921603.1 hypothetical protein -
KAF59_RS15320 (KAF59_15320) 330753..331139 + 387 WP_000703163.1 VOC family protein -
KAF59_RS15325 (KAF59_15325) 331334..331585 + 252 WP_001890111.1 TIGR03643 family protein -
KAF59_RS15330 (KAF59_15330) 331558..331707 + 150 WP_071908333.1 DUF3265 domain-containing protein -
KAF59_RS15335 (KAF59_15335) 331799..332041 + 243 WP_000107461.1 hypothetical protein -
KAF59_RS15340 (KAF59_15340) 332293..332571 + 279 WP_000280324.1 DUF3709 domain-containing protein -
KAF59_RS18815 333003..333046 + 44 Protein_302 hypothetical protein -
KAF59_RS18820 333028..333121 + 94 Protein_303 ggdef family protein -
KAF59_RS18825 333090..333221 + 132 WP_001883067.1 hypothetical protein -
KAF59_RS15355 (KAF59_15355) 333393..333860 + 468 WP_001289288.1 OsmC family protein -
KAF59_RS15360 (KAF59_15360) 333988..334650 + 663 WP_000960654.1 hypothetical protein -
KAF59_RS18830 334640..334768 + 129 WP_088124358.1 DUF3265 domain-containing protein -
KAF59_RS15365 (KAF59_15365) 334835..335101 + 267 WP_000589156.1 BrnT family toxin Toxin
KAF59_RS15370 (KAF59_15370) 335088..335333 + 246 WP_000643598.1 hypothetical protein Antitoxin
KAF59_RS15375 (KAF59_15375) 335429..336223 + 795 WP_001911581.1 hypothetical protein -
KAF59_RS18835 336220..336336 + 117 WP_086010881.1 DUF3265 domain-containing protein -
KAF59_RS15380 (KAF59_15380) 336326..336454 + 129 WP_071908338.1 general secretion pathway protein GspI -
KAF59_RS15385 (KAF59_15385) 336515..336697 + 183 WP_000923182.1 DUF645 family protein -
KAF59_RS15390 (KAF59_15390) 336897..337370 + 474 WP_001161076.1 GrpB family protein -
KAF59_RS15395 (KAF59_15395) 337385..337477 + 93 WP_014378730.1 DUF3265 domain-containing protein -
KAF59_RS15400 (KAF59_15400) 337519..338145 + 627 WP_000365424.1 LysE family translocator -
KAF59_RS15405 (KAF59_15405) 338268..338966 + 699 WP_001890502.1 hypothetical protein -
KAF59_RS15410 (KAF59_15410) 338997..339086 + 90 WP_072606010.1 DUF3265 domain-containing protein -
KAF59_RS15415 (KAF59_15415) 339664..339843 + 180 WP_001883058.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T199001 WP_000589156.1 NZ_CP072850:334835-335101 [Vibrio cholerae MO10]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T199001 NZ_CP097083:87269-87739 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT199001 WP_000643598.1 NZ_CP072850:335088-335333 [Vibrio cholerae MO10]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT199001 NZ_CP097083:86829-87272 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References