Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 374668..375196 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GTF75_RS15790 Protein ID WP_000221352.1
Coordinates 374668..374958 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GTF75_RS15795 Protein ID WP_000213183.1
Coordinates 374948..375196 (-) Length 83 a.a.

Genomic Context

GTF75_RS15745GTF75_RS15750GTF75_RS15755GTF75_RS15760GTF75_RS15765GTF75_RS15770GTF75_RS15775GTF75_RS15780GTF75_RS15785GTF75_RS15800GTF75_RS15805GTF75_RS15810GTF75_RS15815GTF75_RS15820GTF75_RS15825GTF75_RS15790GTF75_RS15795GTF75_RS15830
Location: 369938..370048 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 370225..370350 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 370366..370404 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 370617..371621 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 371774..372220 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 372340..373269 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 373266..373376 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 373404..373880 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 374017..374532 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 375767..376420 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 376692..377117 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 377325..377720 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 377871..378401 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 378539..379039 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 379195..379593 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 374668..374958 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 374948..375196 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 379693..380157 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF75_RS15745369938..370048+111WP_134814058.1DUF3265 domain-containing protein-
GTF75_RS15750370225..370350+126WP_001944767.1DUF645 family protein-
GTF75_RS15755370366..370404+39WP_106019119.1hypothetical protein-
GTF75_RS15760370617..371621+1005WP_000964925.1LD-carboxypeptidase-
GTF75_RS15765371774..372220+447WP_000128977.1hypothetical protein-
GTF75_RS15770372340..373269+930WP_000335802.1hypothetical protein-
GTF75_RS15775373266..373376+111WP_071917832.1DUF3265 domain-containing protein-
GTF75_RS15780373404..373880+477WP_001047180.1GNAT family N-acetyltransferase-
GTF75_RS15785374017..374532+516WP_001201528.1lipocalin family protein-
GTF75_RS15790374668..374958-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF75_RS15795374948..375196-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GTF75_RS15800375767..376420+654WP_000036957.1site-specific DNA-methyltransferase-
GTF75_RS15805376692..377117+426WP_000415748.1hypothetical protein-
GTF75_RS15810377325..377720+396WP_000649527.1DUF3465 domain-containing protein-
GTF75_RS15815377871..378401+531WP_000415563.1hypothetical protein-
GTF75_RS15820378539..379039+501WP_000789723.1hypothetical protein-
GTF75_RS15825379195..379593+399WP_001882293.1hypothetical protein-
GTF75_RS15830379693..380157-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305935..411136105201
insideIntegron--311015..41076099745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T145872 WP_000221352.1 NZ_CP047302:c374958-374668 [Vibrio cholerae O1 biovar El Tor]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T145872 NZ_CP062705:2694910-2695065 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT145872 WP_000213183.1 NZ_CP047302:c375196-374948 [Vibrio cholerae O1 biovar El Tor]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT145872 NZ_CP062705:c2694898-2694840 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References