145872

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 374668..375196 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GTF75_RS15790 Protein ID WP_000221352.1
Coordinates 374668..374958 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GTF75_RS15795 Protein ID WP_000213183.1
Coordinates 374948..375196 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF75_RS15745 369938..370048 + 111 WP_134814058.1 DUF3265 domain-containing protein -
GTF75_RS15750 370225..370350 + 126 WP_001944767.1 DUF645 family protein -
GTF75_RS15755 370366..370404 + 39 WP_106019119.1 hypothetical protein -
GTF75_RS15760 370617..371621 + 1005 WP_000964925.1 LD-carboxypeptidase -
GTF75_RS15765 371774..372220 + 447 WP_000128977.1 hypothetical protein -
GTF75_RS15770 372340..373269 + 930 WP_000335802.1 hypothetical protein -
GTF75_RS15775 373266..373376 + 111 WP_071917832.1 DUF3265 domain-containing protein -
GTF75_RS15780 373404..373880 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
GTF75_RS15785 374017..374532 + 516 WP_001201528.1 lipocalin family protein -
GTF75_RS15790 374668..374958 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF75_RS15795 374948..375196 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF75_RS15800 375767..376420 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
GTF75_RS15805 376692..377117 + 426 WP_000415748.1 hypothetical protein -
GTF75_RS15810 377325..377720 + 396 WP_000649527.1 DUF3465 domain-containing protein -
GTF75_RS15815 377871..378401 + 531 WP_000415563.1 hypothetical protein -
GTF75_RS15820 378539..379039 + 501 WP_000789723.1 hypothetical protein -
GTF75_RS15825 379195..379593 + 399 WP_001882293.1 hypothetical protein -
GTF75_RS15830 379693..380157 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305935..411136 105201
inside Integron - - 311015..410760 99745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T145872 WP_000221352.1 NZ_CP047302:c374958-374668 [Vibrio cholerae O1 biovar El Tor]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T145872 NZ_CP062705:2694910-2695065 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT145872 WP_000213183.1 NZ_CP047302:c375196-374948 [Vibrio cholerae O1 biovar El Tor]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT145872 NZ_CP062705:c2694898-2694840 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References