Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 803208..803779 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag NW313_RS17830 Protein ID WP_000351248.1
Coordinates 803378..803779 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag NW313_RS17825 Protein ID WP_001080654.1
Coordinates 803208..803378 (+) Length 57 a.a.

Genomic Context

NW313_RS17770NW313_RS17775NW313_RS17780NW313_RS17785NW313_RS17790NW313_RS17795NW313_RS17800NW313_RS17805NW313_RS17815NW313_RS17820NW313_RS17825NW313_RS17830NW313_RS17835NW313_RS17840NW313_RS17845NW313_RS17850NW313_RS17855NW313_RS17860NW313_RS17865NW313_RS17870NW313_RS17885NW313_RS17890NW313_RS17895NW313_RS17810NW313_RS17875NW313_RS17880
Location: 798403..798517 (115 bp)
Type: Others
Protein ID: Protein_777
Location: 798526..798747 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 798913..799026 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 798975..799202 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 799543..799875 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 799862..800176 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 800313..800747 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 800915..801070 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 802243..802549 (307 bp)
Type: Others
Protein ID: Protein_786
Location: 802686..803084 (399 bp)
Type: Others
Protein ID: Protein_787
Location: 803208..803378 (171 bp)
Type: Antitoxin
Protein ID: WP_001080654.1
Location: 803378..803779 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 803782..803892 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 803967..804380 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 804594..804845 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 804835..805122 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 805250..805705 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 805762..805884 (123 bp)
Type: Others
Protein ID: Protein_795
Location: 806055..806179 (125 bp)
Type: Others
Protein ID: Protein_796
Location: 806296..806364 (69 bp)
Type: Others
Protein ID: Protein_797
Location: 807299..807361 (63 bp)
Type: Others
Protein ID: Protein_800
Location: 807378..808046 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 808198..808485 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 801195..802175 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 806381..806878 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 806875..807147 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NW313_RS17770798403..798517+115Protein_777acetyltransferase-
NW313_RS17775798526..798747+222WP_032468461.1DUF1289 domain-containing protein-
NW313_RS17780798913..799026+114WP_001889158.1hypothetical protein-
NW313_RS17785798975..799202+228WP_073426587.1DUF1289 domain-containing protein-
NW313_RS17790799543..799875+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
NW313_RS17795799862..800176+315WP_000071008.1DNA-binding transcriptional regulator-
NW313_RS17800800313..800747+435WP_000256036.1GNAT family N-acetyltransferase-
NW313_RS17805800915..801070+156WP_000751734.1hypothetical protein-
NW313_RS17810801195..802175-981WP_000019370.1IS5-like element ISVch5 family transposase-
NW313_RS17815802243..802549+307Protein_786CatB-related O-acetyltransferase-
NW313_RS17820802686..803084+399Protein_787GNAT family N-acetyltransferase-
NW313_RS17825803208..803378+171WP_001080654.1hypothetical proteinAntitoxin
NW313_RS17830803378..803779+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
NW313_RS17835803782..803892+111WP_082798255.1DUF3265 domain-containing protein-
NW313_RS17840803967..804380+414WP_000049417.1VOC family protein-
NW313_RS17845804594..804845+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
NW313_RS17850804835..805122+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
NW313_RS17855805250..805705+456WP_001245327.1GNAT family N-acetyltransferase-
NW313_RS17860805762..805884+123Protein_795acetyltransferase-
NW313_RS17865806055..806179+125Protein_796DUF645 family protein-
NW313_RS17870806296..806364+69Protein_797acetyltransferase-
NW313_RS17875806381..806878-498WP_000982260.1GNAT family N-acetyltransferase-
NW313_RS17880806875..807147-273WP_000246253.1DUF1778 domain-containing protein-
NW313_RS17885807299..807361+63Protein_800acetyltransferase-
NW313_RS17890807378..808046+669WP_000043871.1hypothetical protein-
NW313_RS17895808198..808485+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-713852..820357106505
insideIntegroncatB9-718932..819981101049
flankIS/Tn--801195..802175980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T254475 WP_000351248.1 NZ_CP102928:803378-803779 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT254475 WP_001080654.1 NZ_CP102928:803208-803378 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SJJ1

References