Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 367479..367977 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag ASZ79_RS16055 Protein ID WP_000589156.1
Coordinates 367479..367745 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag ASZ79_RS16060 Protein ID WP_000643598.1
Coordinates 367732..367977 (+) Length 82 a.a.

Genomic Context

ASZ79_RS20575ASZ79_RS20580ASZ79_RS16010ASZ79_RS16015ASZ79_RS16020ASZ79_RS16025ASZ79_RS16030ASZ79_RS20990ASZ79_RS20995ASZ79_RS16045ASZ79_RS16050ASZ79_RS16055ASZ79_RS16060ASZ79_RS16065ASZ79_RS21000ASZ79_RS16080ASZ79_RS16085ASZ79_RS16090ASZ79_RS16095ASZ79_RS16100ASZ79_RS16105
Location: 362900..363106 (207 bp)
Type: Others
Protein ID: Protein_347
Location: 363306..363407 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 363397..363783 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 363978..364229 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 364202..364351 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 364443..364685 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 364937..365215 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 365590..365733 (144 bp)
Type: Others
Protein ID: Protein_354
Location: 365787..365825 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 366037..366504 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 366632..367294 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 367479..367745 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 367732..367977 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 368073..368867 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 368970..369098 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 369159..369341 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 369557..370561 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 370714..371073 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 371346..371579 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 371847..372353 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 372510..372896 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS20575362900..363106+207Protein_347DUF3709 domain-containing protein-
ASZ79_RS20580363306..363407+102WP_001921603.1hypothetical protein-
ASZ79_RS16010363397..363783+387WP_000703163.1VOC family protein-
ASZ79_RS16015363978..364229+252WP_001890111.1TIGR03643 family protein-
ASZ79_RS16020364202..364351+150WP_071908333.1DUF3265 domain-containing protein-
ASZ79_RS16025364443..364685+243WP_000107461.1hypothetical protein-
ASZ79_RS16030364937..365215+279WP_000280324.1DUF3709 domain-containing protein-
ASZ79_RS20990365590..365733+144Protein_354DUF645 family protein-
ASZ79_RS20995365787..365825+39WP_082798268.1hypothetical protein-
ASZ79_RS16045366037..366504+468WP_001289288.1OsmC family protein-
ASZ79_RS16050366632..367294+663WP_000960654.1hypothetical protein-
ASZ79_RS16055367479..367745+267WP_000589156.1BrnT family toxinToxin
ASZ79_RS16060367732..367977+246WP_000643598.1hypothetical proteinAntitoxin
ASZ79_RS16065368073..368867+795WP_001911581.1hypothetical protein-
ASZ79_RS21000368970..369098+129WP_071908338.1general secretion pathway protein GspI-
ASZ79_RS16080369159..369341+183WP_000923182.1DUF645 family protein-
ASZ79_RS16085369557..370561+1005WP_000964920.1LD-carboxypeptidase-
ASZ79_RS16090370714..371073+360WP_001071541.1VOC family protein-
ASZ79_RS16095371346..371579+234WP_001890112.1DUF3709 domain-containing protein-
ASZ79_RS16100371847..372353+507WP_000393074.1hypothetical protein-
ASZ79_RS16105372510..372896+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T58356 WP_000589156.1 NZ_CP013314:367479-367745 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T58356 NZ_CP013314:367479-367745 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT58356 WP_000643598.1 NZ_CP013314:367732-367977 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT58356 NZ_CP013314:367732-367977 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References