Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 328014..328554 Replicon chromosome
Accession NZ_LT906615
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag FY484_RS15415 Protein ID WP_000277238.1
Coordinates 328014..328283 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag FY484_RS15420 Protein ID WP_001258569.1
Coordinates 328276..328554 (-) Length 93 a.a.

Genomic Context

FY484_RS15350FY484_RS15355FY484_RS15360FY484_RS15375FY484_RS15380FY484_RS15395FY484_RS15400FY484_RS15410FY484_RS15430FY484_RS15435FY484_RS15440FY484_RS15445FY484_RS15450FY484_RS15455FY484_RS15460FY484_RS15465FY484_RS19505FY484_RS19510FY484_RS15480FY484_RS15345FY484_RS15385FY484_RS15390FY484_RS15415FY484_RS15420
Location: 323504..323890 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 323947..324060 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324009..324290 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 324548..325084 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 325221..325736 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 327045..327170 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 327186..327224 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 327420..327866 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 328840..329118 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 329370..329576 (207 bp)
Type: Others
Protein ID: Protein_292
Location: 329776..329877 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329867..330253 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330448..330699 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330672..330821 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330913..331155 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 331407..331685 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332060..332203 (144 bp)
Type: Others
Protein ID: Protein_299
Location: 332257..332295 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 332507..332974 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 323018..323260 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 325886..326383 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 326380..326652 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 328014..328283 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 328276..328554 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FY484_RS15345323018..323260-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FY484_RS15350323504..323890+387WP_001015867.1NUDIX hydrolase-
FY484_RS15355323947..324060+114WP_001900214.1hypothetical protein-
FY484_RS15360324009..324290+282WP_001894429.1DUF1289 domain-containing protein-
FY484_RS15375324548..325084+537WP_000469482.1GNAT family N-acetyltransferase-
FY484_RS15380325221..325736+516WP_001201509.1lipocalin family protein-
FY484_RS15385325886..326383-498WP_000982260.1GNAT family N-acetyltransferase-
FY484_RS15390326380..326652-273WP_000246253.1DUF1778 domain-containing protein-
FY484_RS15395327045..327170+126WP_001900195.1DUF645 family protein-
FY484_RS15400327186..327224+39WP_106019118.1hypothetical protein-
FY484_RS15410327420..327866+447WP_000006157.1hypothetical protein-
FY484_RS15415328014..328283-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
FY484_RS15420328276..328554-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
FY484_RS15430328840..329118+279WP_001921601.1DUF3709 domain-containing protein-
FY484_RS15435329370..329576+207Protein_292DUF3709 domain-containing protein-
FY484_RS15440329776..329877+102WP_001921603.1hypothetical protein-
FY484_RS15445329867..330253+387WP_000703163.1VOC family protein-
FY484_RS15450330448..330699+252WP_001890111.1TIGR03643 family protein-
FY484_RS15455330672..330821+150WP_071908333.1DUF3265 domain-containing protein-
FY484_RS15460330913..331155+243WP_000107461.1hypothetical protein-
FY484_RS15465331407..331685+279WP_000280324.1DUF3709 domain-containing protein-
FY484_RS19505332060..332203+144Protein_299DUF645 family protein-
FY484_RS19510332257..332295+39WP_082798268.1hypothetical protein-
FY484_RS15480332507..332974+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T293794 WP_000277238.1 NZ_LT906615:c328283-328014 [Vibrio cholerae O1 biovar El Tor str. N16961]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT293794 WP_001258569.1 NZ_LT906615:c328554-328276 [Vibrio cholerae O1 biovar El Tor str. N16961]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References