74620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 764322..764850 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag A6J62_RS03505 Protein ID WP_000221354.1
Coordinates 764322..764609 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag A6J62_RS03510 Protein ID WP_001250179.1
Coordinates 764599..764850 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J62_RS03455 759425..759958 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
A6J62_RS19635 759955..760380 - 426 WP_001882332.1 DUF1778 domain-containing protein -
A6J62_RS03465 760447..760818 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
A6J62_RS03470 760959..761246 - 288 WP_000426470.1 hypothetical protein -
A6J62_RS03475 761398..762066 - 669 WP_000043871.1 hypothetical protein -
A6J62_RS03480 762297..762569 + 273 WP_000246253.1 DUF1778 domain-containing protein -
A6J62_RS03485 762566..763063 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
A6J62_RS03495 763265..763417 - 153 WP_001884520.1 DUF645 family protein -
A6J62_RS03500 763739..764194 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
A6J62_RS03505 764322..764609 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J62_RS03510 764599..764850 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A6J62_RS03515 765064..765477 - 414 WP_000049417.1 VOC family protein -
A6J62_RS03520 765552..765695 - 144 WP_071908341.1 DUF3265 domain-containing protein -
A6J62_RS03525 765665..766066 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
A6J62_RS03530 766066..766758 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
A6J62_RS03535 766929..767201 - 273 Protein_667 CatB-related O-acetyltransferase -
A6J62_RS03540 767269..768249 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
A6J62_RS19640 768374..768529 - 156 WP_000751734.1 hypothetical protein -
A6J62_RS03545 768697..769131 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
A6J62_RS03550 769268..769582 - 315 WP_000071008.1 DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 749087..881909 132822
inside Integron - - 749463..875103 125640
flank IS/Tn - - 767269..768249 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T74620 WP_000221354.1 NZ_CP020407:c764609-764322 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T74620 NZ_CP020407:c764609-764322 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT74620 WP_001250179.1 NZ_CP020407:c764850-764599 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT74620 NZ_CP020407:c764850-764599 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References