Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 394802..395340 Replicon chromosome
Accession NZ_OW443148
Organism Vibrio cholerae strain CNRVC190243 isolate YE-NCPHL-19014-PI

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag OC617_RS15785 Protein ID WP_000802136.1
Coordinates 394802..395101 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag OC617_RS15790 Protein ID WP_001107719.1
Coordinates 395098..395340 (-) Length 81 a.a.

Genomic Context

OC617_RS15740OC617_RS15745OC617_RS15750OC617_RS15755OC617_RS15760OC617_RS15765OC617_RS15770OC617_RS15775OC617_RS15780OC617_RS15795OC617_RS15800OC617_RS15805OC617_RS15810OC617_RS15815OC617_RS15820OC617_RS15825OC617_RS15785OC617_RS15790
Location: 390539..390676 (138 bp)
Type: Others
Protein ID: WP_001890145.1
Location: 390737..390919 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 391119..391592 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 391607..391699 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 391741..392367 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 392490..393188 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 393219..393308 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 393886..394065 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 394279..394674 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 395569..396147 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 396169..396261 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 396685..397368 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 397582..397848 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 398003..398602 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 398883..399818 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 399784..399924 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 394802..395101 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 395098..395340 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OC617_RS15740390539..390676+138WP_001890145.1hypothetical protein-
OC617_RS15745390737..390919+183WP_000923182.1DUF645 family protein-
OC617_RS15750 (CNRVC190243H_03115)391119..391592+474WP_001161076.1GrpB family protein-
OC617_RS15755391607..391699+93WP_014378730.1DUF3265 domain-containing protein-
OC617_RS15760 (CNRVC190243H_03116)391741..392367+627WP_000365424.1LysE family translocator-
OC617_RS15765 (CNRVC190243H_03117)392490..393188+699WP_001890502.1hypothetical protein-
OC617_RS15770393219..393308+90WP_072606010.1DUF3265 domain-containing protein-
OC617_RS15775393886..394065+180WP_001883058.1DUF645 family protein-
OC617_RS15780 (CNRVC190243H_03119)394279..394674+396WP_000870857.1DUF3465 domain-containing protein-
OC617_RS15785 (CNRVC190243H_03120)394802..395101-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
OC617_RS15790 (CNRVC190243H_03121)395098..395340-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
OC617_RS15795 (CNRVC190243H_03122)395569..396147+579WP_000110120.1hypothetical protein-
OC617_RS15800396169..396261+93WP_014164112.1DUF3265 domain-containing protein-
OC617_RS15805 (CNRVC190243H_03124)396685..397368+684WP_000877436.1hypothetical protein-
OC617_RS15810 (CNRVC190243H_03125)397582..397848+267WP_000937852.1hypothetical protein-
OC617_RS15815 (CNRVC190243H_03126)398003..398602+600WP_000429495.1DUF6338 family protein-
OC617_RS15820 (CNRVC190243H_03127)398883..399818+936WP_000051985.1restriction endonuclease-
OC617_RS15825399784..399924+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-349905..456410106505
insideIntegroncatB9-354985..456034101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T295391 WP_000802136.1 NZ_OW443148:c395101-394802 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT295391 WP_001107719.1 NZ_OW443148:c395340-395098 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References