295391

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 394802..395340 Replicon chromosome
Accession NZ_OW443148
Organism Vibrio cholerae strain CNRVC190243 isolate YE-NCPHL-19014-PI

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag OC617_RS15785 Protein ID WP_000802136.1
Coordinates 394802..395101 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag OC617_RS15790 Protein ID WP_001107719.1
Coordinates 395098..395340 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OC617_RS15740 390539..390676 + 138 WP_001890145.1 hypothetical protein -
OC617_RS15745 390737..390919 + 183 WP_000923182.1 DUF645 family protein -
OC617_RS15750 (CNRVC190243H_03115) 391119..391592 + 474 WP_001161076.1 GrpB family protein -
OC617_RS15755 391607..391699 + 93 WP_014378730.1 DUF3265 domain-containing protein -
OC617_RS15760 (CNRVC190243H_03116) 391741..392367 + 627 WP_000365424.1 LysE family translocator -
OC617_RS15765 (CNRVC190243H_03117) 392490..393188 + 699 WP_001890502.1 hypothetical protein -
OC617_RS15770 393219..393308 + 90 WP_072606010.1 DUF3265 domain-containing protein -
OC617_RS15775 393886..394065 + 180 WP_001883058.1 DUF645 family protein -
OC617_RS15780 (CNRVC190243H_03119) 394279..394674 + 396 WP_000870857.1 DUF3465 domain-containing protein -
OC617_RS15785 (CNRVC190243H_03120) 394802..395101 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OC617_RS15790 (CNRVC190243H_03121) 395098..395340 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
OC617_RS15795 (CNRVC190243H_03122) 395569..396147 + 579 WP_000110120.1 hypothetical protein -
OC617_RS15800 396169..396261 + 93 WP_014164112.1 DUF3265 domain-containing protein -
OC617_RS15805 (CNRVC190243H_03124) 396685..397368 + 684 WP_000877436.1 hypothetical protein -
OC617_RS15810 (CNRVC190243H_03125) 397582..397848 + 267 WP_000937852.1 hypothetical protein -
OC617_RS15815 (CNRVC190243H_03126) 398003..398602 + 600 WP_000429495.1 DUF6338 family protein -
OC617_RS15820 (CNRVC190243H_03127) 398883..399818 + 936 WP_000051985.1 restriction endonuclease -
OC617_RS15825 399784..399924 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 349905..456410 106505
inside Integron catB9 - 354985..456034 101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T295391 WP_000802136.1 NZ_OW443148:c395101-394802 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT295391 WP_001107719.1 NZ_OW443148:c395340-395098 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References