58354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 359416..360182 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ79_RS15975 Protein ID WP_000982260.1
Coordinates 359416..359913 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ79_RS15980 Protein ID WP_000246253.1
Coordinates 359910..360182 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ79_RS15925 354858..355562 + 705 WP_000087610.1 HNH endonuclease -
ASZ79_RS15930 355720..356058 + 339 WP_000713853.1 hypothetical protein -
ASZ79_RS15935 356212..356529 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ79_RS15940 356548..356790 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ79_RS15945 357034..357420 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ79_RS15950 357477..357590 + 114 WP_001900214.1 hypothetical protein -
ASZ79_RS15955 357539..357820 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ79_RS15965 358078..358614 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ79_RS15970 358751..359266 + 516 WP_001201509.1 lipocalin family protein -
ASZ79_RS15975 359416..359913 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
ASZ79_RS15980 359910..360182 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
ASZ79_RS20555 360575..360700 + 126 WP_001900195.1 DUF645 family protein -
ASZ79_RS20560 360716..360754 + 39 WP_106019118.1 hypothetical protein -
ASZ79_RS15990 360950..361396 + 447 WP_000006157.1 hypothetical protein -
ASZ79_RS15995 361544..361813 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
ASZ79_RS16000 361806..362084 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ79_RS16005 362370..362648 + 279 WP_001921601.1 DUF3709 domain-containing protein -
ASZ79_RS20575 362900..363106 + 207 Protein_347 DUF3709 domain-containing protein -
ASZ79_RS20580 363306..363407 + 102 WP_001921603.1 hypothetical protein -
ASZ79_RS16010 363397..363783 + 387 WP_000703163.1 VOC family protein -
ASZ79_RS16015 363978..364229 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ79_RS16020 364202..364351 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ79_RS16025 364443..364685 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..468464 163764
inside Integron - - 309780..468088 158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58354 WP_000982260.1 NZ_CP013314:c359913-359416 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58354 NZ_CP013314:c359913-359416 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58354 WP_000246253.1 NZ_CP013314:c360182-359910 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58354 NZ_CP013314:c360182-359910 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References