Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 328886..329426 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag J9265_RS15215 Protein ID WP_000277238.1
Coordinates 328886..329155 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag J9265_RS15220 Protein ID WP_001258569.1
Coordinates 329148..329426 (-) Length 93 a.a.

Genomic Context

J9265_RS15165J9265_RS15170J9265_RS15175J9265_RS15180J9265_RS15185J9265_RS19000J9265_RS15200J9265_RS15210J9265_RS19005J9265_RS15225J9265_RS19010J9265_RS15235J9265_RS15240J9265_RS15245J9265_RS15250J9265_RS15255J9265_RS15260J9265_RS19015J9265_RS19020J9265_RS19025J9265_RS15275J9265_RS15160J9265_RS15190J9265_RS15195J9265_RS15215J9265_RS15220
Location: 324376..324762 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 324819..324932 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324941..325162 (222 bp)
Type: Others
Protein ID: WP_032467793.1
Location: 325420..325956 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 326147..326608 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 326673..326741 (69 bp)
Type: Others
Protein ID: Protein_286
Location: 327917..328042 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 328292..328738 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 329477..329594 (118 bp)
Type: Others
Protein ID: Protein_293
Location: 329712..329990 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 330350..330448 (99 bp)
Type: Others
Protein ID: WP_223225486.1
Location: 330648..330749 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 330739..331125 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 331320..331571 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 331544..331693 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 331785..332027 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 332279..332557 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332989..333032 (44 bp)
Type: Others
Protein ID: Protein_302
Location: 333014..333107 (94 bp)
Type: Others
Protein ID: Protein_303
Location: 333076..333207 (132 bp)
Type: Others
Protein ID: WP_001883067.1
Location: 333379..333846 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 323890..324132 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 326758..327255 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 327252..327524 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 328886..329155 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 329148..329426 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J9265_RS15160 (J9265_15160)323890..324132-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
J9265_RS15165 (J9265_15165)324376..324762+387WP_001015867.1NUDIX hydrolase-
J9265_RS15170 (J9265_15170)324819..324932+114WP_001900214.1hypothetical protein-
J9265_RS15175 (J9265_15175)324941..325162+222WP_032467793.1DUF1289 domain-containing protein-
J9265_RS15180 (J9265_15180)325420..325956+537WP_000469482.1GNAT family protein-
J9265_RS15185 (J9265_15185)326147..326608+462WP_001903091.1lipocalin family protein-
J9265_RS19000326673..326741+69Protein_286acetyltransferase-
J9265_RS15190 (J9265_15190)326758..327255-498WP_000982260.1GNAT family N-acetyltransferase-
J9265_RS15195 (J9265_15195)327252..327524-273WP_000246253.1DUF1778 domain-containing protein-
J9265_RS15200 (J9265_15200)327917..328042+126WP_001900195.1DUF645 family protein-
J9265_RS15210 (J9265_15210)328292..328738+447WP_000006157.1hypothetical protein-
J9265_RS15215 (J9265_15215)328886..329155-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
J9265_RS15220 (J9265_15220)329148..329426-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
J9265_RS19005329477..329594+118Protein_293DUF3265 domain-containing protein-
J9265_RS15225 (J9265_15225)329712..329990+279WP_001921601.1DUF3709 domain-containing protein-
J9265_RS19010330350..330448+99WP_223225486.1DUF3709 domain-containing protein-
J9265_RS15235 (J9265_15235)330648..330749+102WP_001921603.1hypothetical protein-
J9265_RS15240 (J9265_15240)330739..331125+387WP_000703163.1VOC family protein-
J9265_RS15245 (J9265_15245)331320..331571+252WP_001890111.1TIGR03643 family protein-
J9265_RS15250 (J9265_15250)331544..331693+150WP_071908333.1DUF3265 domain-containing protein-
J9265_RS15255 (J9265_15255)331785..332027+243WP_000107461.1hypothetical protein-
J9265_RS15260 (J9265_15260)332279..332557+279WP_000280324.1DUF3709 domain-containing protein-
J9265_RS19015332989..333032+44Protein_302hypothetical protein-
J9265_RS19020333014..333107+94Protein_303ggdef family protein-
J9265_RS19025333076..333207+132WP_001883067.1hypothetical protein-
J9265_RS15275 (J9265_15275)333379..333846+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T198980 WP_000277238.1 NZ_CP072848:c329155-328886 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T198980 NZ_CP072848:c329155-328886 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT198980 WP_001258569.1 NZ_CP072848:c329426-329148 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT198980 NZ_CP072848:c329426-329148 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References