Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 102887..103686 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag K6J77_RS14700 Protein ID WP_000118351.1
Coordinates 103153..103686 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag K6J77_RS19110 Protein ID WP_000179600.1
Coordinates 102887..103156 (+) Length 90 a.a.

Genomic Context

K6J77_RS14650K6J77_RS14655K6J77_RS14660K6J77_RS19095K6J77_RS14665K6J77_RS19100K6J77_RS19105K6J77_RS14680K6J77_RS14685K6J77_RS14690K6J77_RS19110K6J77_RS14700K6J77_RS19115K6J77_RS14705K6J77_RS14710K6J77_RS14715K6J77_RS14720K6J77_RS14725K6J77_RS14730K6J77_RS14735K6J77_RS14740K6J77_RS14670K6J77_RS14675
Location: 98261..98512 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 98502..98789 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 98917..99372 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 99429..99551 (123 bp)
Type: Others
Protein ID: Protein_188
Location: 99722..99846 (125 bp)
Type: Others
Protein ID: Protein_189
Location: 99963..100031 (69 bp)
Type: Others
Protein ID: Protein_190
Location: 100966..101028 (63 bp)
Type: Others
Protein ID: Protein_193
Location: 101045..101713 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 101865..102152 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 102293..102664 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 102887..103156 (270 bp)
Type: Antitoxin
Protein ID: WP_000179600.1
Location: 103153..103686 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 103696..103806 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 103888..104145 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 104133..104435 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 104669..105586 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 105743..106132 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 106268..106477 (210 bp)
Type: Others
Protein ID: Protein_204
Location: 106596..107033 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 107094..107315 (222 bp)
Type: Others
Protein ID: Protein_206
Location: 107490..108362 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 100048..100545 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 100542..100814 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J77_RS1465098261..98512+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J77_RS1465598502..98789+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J77_RS1466098917..99372+456WP_001245327.1GNAT family N-acetyltransferase-
K6J77_RS1909599429..99551+123Protein_188acetyltransferase-
K6J77_RS1466599722..99846+125Protein_189DUF645 family protein-
K6J77_RS1910099963..100031+69Protein_190acetyltransferase-
K6J77_RS14670100048..100545-498WP_000982260.1GNAT family N-acetyltransferase-
K6J77_RS14675100542..100814-273WP_000246253.1DUF1778 domain-containing protein-
K6J77_RS19105100966..101028+63Protein_193acetyltransferase-
K6J77_RS14680101045..101713+669WP_000043871.1hypothetical protein-
K6J77_RS14685101865..102152+288WP_000426470.1hypothetical protein-
K6J77_RS14690102293..102664+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
K6J77_RS19110102887..103156+270WP_000179600.1DUF1778 domain-containing proteinAntitoxin
K6J77_RS14700103153..103686+534WP_000118351.1GNAT family N-acetyltransferaseToxin
K6J77_RS19115103696..103806+111WP_086010065.1DUF3265 domain-containing protein-
K6J77_RS14705103888..104145+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J77_RS14710104133..104435+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J77_RS14715104669..105586+918WP_000186333.1alpha/beta hydrolase-
K6J77_RS14720105743..106132+390WP_001081302.1hypothetical protein-
K6J77_RS14725106268..106477+210Protein_204GNAT family N-acetyltransferase-
K6J77_RS14730106596..107033+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
K6J77_RS14735107094..107315+222Protein_206GNAT family N-acetyltransferase-
K6J77_RS14740107490..108362+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--11978..113648101670
flankIS/Tn--106596..107033437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T38629 WP_000118351.1 NZ_AP024548:103153-103686 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T38629 NZ_AP024548:103153-103686 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT38629 WP_000179600.1 NZ_AP024548:102887-103156 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT38629 NZ_AP024548:102887-103156 [Vibrio cholerae]
ATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTT
AAAAAGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGG
TTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTT
AAATTTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0K9UER4

References