Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 837812..838371 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag LZM82_RS17225 Protein ID WP_000578476.1
Coordinates 838093..838371 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag LZM82_RS17220 Protein ID WP_000381183.1
Coordinates 837812..838096 (+) Length 95 a.a.

Genomic Context

LZM82_RS17220LZM82_RS17225LZM82_RS17210LZM82_RS17215LZM82_RS17230LZM82_RS17235LZM82_RS17240LZM82_RS17245LZM82_RS17250LZM82_RS17255LZM82_RS17260LZM82_RS17265LZM82_RS17270
Location: 837812..838096 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 838093..838371 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 836506..836919 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 837103..837618 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 838510..838905 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 839156..839281 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 839580..840101 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 840095..840364 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 840431..840499 (69 bp)
Type: Others
Protein ID: Protein_717
Location: 840556..841155 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 841305..842177 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 842352..842573 (222 bp)
Type: Others
Protein ID: Protein_720
Location: 842634..843071 (438 bp)
Type: Others
Protein ID: WP_000503164.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZM82_RS17210 (LZM82_17210)836506..836919-414WP_000049420.1VOC family protein-
LZM82_RS17215 (LZM82_17215)837103..837618-516WP_000343779.1GNAT family protein-
LZM82_RS17220 (LZM82_17220)837812..838096+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
LZM82_RS17225 (LZM82_17225)838093..838371+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
LZM82_RS17230 (LZM82_17230)838510..838905-396WP_001000867.1hypothetical protein-
LZM82_RS17235 (LZM82_17235)839156..839281-126WP_001905700.1DUF645 family protein-
LZM82_RS17240 (LZM82_17240)839580..840101-522WP_000921691.1DUF2442 domain-containing protein-
LZM82_RS17245 (LZM82_17245)840095..840364-270WP_001114075.1DUF4160 domain-containing protein-
LZM82_RS17250 (LZM82_17250)840431..840499-69Protein_717acetyltransferase-
LZM82_RS17255 (LZM82_17255)840556..841155-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
LZM82_RS17260 (LZM82_17260)841305..842177-873WP_000254716.1DUF3800 domain-containing protein-
LZM82_RS17265 (LZM82_17265)842352..842573-222Protein_720GNAT family N-acetyltransferase-
LZM82_RS17270 (LZM82_17270)842634..843071-438WP_000503164.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-835643..943910108267
insideIntegron--836019..937068101049
flankIS/Tn--842634..843071437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T230635 WP_000578476.1 NZ_CP090400:838093-838371 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T230635 NZ_CP125220:c3987605-3987318 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT230635 WP_000381183.1 NZ_CP090400:837812-838096 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT230635 NZ_CP125220:c3987331-3987029 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References