230635

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 837812..838371 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag LZM82_RS17225 Protein ID WP_000578476.1
Coordinates 838093..838371 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag LZM82_RS17220 Protein ID WP_000381183.1
Coordinates 837812..838096 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17210 (LZM82_17210) 836506..836919 - 414 WP_000049420.1 VOC family protein -
LZM82_RS17215 (LZM82_17215) 837103..837618 - 516 WP_000343779.1 GNAT family protein -
LZM82_RS17220 (LZM82_17220) 837812..838096 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZM82_RS17225 (LZM82_17225) 838093..838371 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LZM82_RS17230 (LZM82_17230) 838510..838905 - 396 WP_001000867.1 hypothetical protein -
LZM82_RS17235 (LZM82_17235) 839156..839281 - 126 WP_001905700.1 DUF645 family protein -
LZM82_RS17240 (LZM82_17240) 839580..840101 - 522 WP_000921691.1 DUF2442 domain-containing protein -
LZM82_RS17245 (LZM82_17245) 840095..840364 - 270 WP_001114075.1 DUF4160 domain-containing protein -
LZM82_RS17250 (LZM82_17250) 840431..840499 - 69 Protein_717 acetyltransferase -
LZM82_RS17255 (LZM82_17255) 840556..841155 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
LZM82_RS17260 (LZM82_17260) 841305..842177 - 873 WP_000254716.1 DUF3800 domain-containing protein -
LZM82_RS17265 (LZM82_17265) 842352..842573 - 222 Protein_720 GNAT family N-acetyltransferase -
LZM82_RS17270 (LZM82_17270) 842634..843071 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049
flank IS/Tn - - 842634..843071 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T230635 WP_000578476.1 NZ_CP090400:838093-838371 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T230635 NZ_CP125220:c3987605-3987318 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT230635 WP_000381183.1 NZ_CP090400:837812-838096 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT230635 NZ_CP125220:c3987331-3987029 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References