Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 457171..458126 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag ASZ79_RS16970 Protein ID WP_000118351.1
Coordinates 457593..458126 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ASZ79_RS16965 Protein ID WP_001882332.1
Coordinates 457171..457596 (+) Length 142 a.a.

Genomic Context

ASZ79_RS16915ASZ79_RS16920ASZ79_RS16925ASZ79_RS16935ASZ79_RS16950ASZ79_RS16955ASZ79_RS16960ASZ79_RS16965ASZ79_RS16970ASZ79_RS16975ASZ79_RS16980ASZ79_RS16985ASZ79_RS16995ASZ79_RS17000ASZ79_RS17005ASZ79_RS17010ASZ79_RS17020ASZ79_RS16940ASZ79_RS16945
Location: 452701..452952 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 452942..453229 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 453357..453812 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 454134..454286 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 455485..456153 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 456305..456592 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 456733..457104 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 457171..457596 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 457593..458126 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 458328..458585 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 458573..458875 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 459109..460026 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 460183..460572 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 460708..460917 (210 bp)
Type: Others
Protein ID: Protein_519
Location: 461036..461473 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 461537..461755 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 461930..462802 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 454488..454985 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 454982..455254 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS16915452701..452952+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ79_RS16920452942..453229+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ79_RS16925453357..453812+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ79_RS16935454134..454286+153WP_001884520.1DUF645 family protein-
ASZ79_RS16940454488..454985-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ79_RS16945454982..455254-273WP_000246253.1DUF1778 domain-containing protein-
ASZ79_RS16950455485..456153+669WP_000043871.1hypothetical protein-
ASZ79_RS16955456305..456592+288WP_000426470.1hypothetical protein-
ASZ79_RS16960456733..457104+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ79_RS16965457171..457596+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
ASZ79_RS16970457593..458126+534WP_000118351.1GNAT family N-acetyltransferaseToxin
ASZ79_RS16975458328..458585+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ79_RS16980458573..458875+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ79_RS16985459109..460026+918WP_000186333.1alpha/beta hydrolase-
ASZ79_RS16995460183..460572+390WP_001081302.1hypothetical protein-
ASZ79_RS17000460708..460917+210Protein_519GNAT family N-acetyltransferase-
ASZ79_RS17005461036..461473+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ79_RS17010461537..461755+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ79_RS17020461930..462802+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308
flankIS/Tn--461036..461473437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T58366 WP_000118351.1 NZ_CP013314:457593-458126 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T58366 NZ_CP013314:457593-458126 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT58366 WP_001882332.1 NZ_CP013314:457171-457596 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT58366 NZ_CP013314:457171-457596 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References