Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 591803..592207 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ87_RS17790 Protein ID WP_001114075.1
Coordinates 591938..592207 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ87_RS20835 Protein ID WP_099607150.1
Coordinates 591803..591907 (+) Length 35 a.a.

Genomic Context

ASZ87_RS17745ASZ87_RS17755ASZ87_RS17760ASZ87_RS17765ASZ87_RS17770ASZ87_RS17780ASZ87_RS17785ASZ87_RS20835ASZ87_RS17790ASZ87_RS17795ASZ87_RS20840ASZ87_RS17810ASZ87_RS17825ASZ87_RS17830ASZ87_RS17815ASZ87_RS17820
Location: 587304..588221 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 588378..588767 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 588903..589112 (210 bp)
Type: Others
Protein ID: Protein_630
Location: 589231..589668 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 589732..589950 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 590125..590997 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 591147..591746 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 591803..591907 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 591938..592207 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 592201..592722 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 593021..593146 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 593397..593792 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 594684..595199 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 595383..595796 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 593931..594209 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 594206..594490 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS17745587304..588221+918WP_000186333.1alpha/beta hydrolase-
ASZ87_RS17755588378..588767+390WP_001081302.1hypothetical protein-
ASZ87_RS17760588903..589112+210Protein_630GNAT family N-acetyltransferase-
ASZ87_RS17765589231..589668+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ87_RS17770589732..589950+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ87_RS17780590125..590997+873WP_000254716.1DUF3800 domain-containing protein-
ASZ87_RS17785591147..591746+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ87_RS20835591803..591907+105WP_099607150.1acetyltransferaseAntitoxin
ASZ87_RS17790591938..592207+270WP_001114075.1DUF4160 domain-containing proteinToxin
ASZ87_RS17795592201..592722+522WP_000921691.1DUF2442 domain-containing protein-
ASZ87_RS20840593021..593146+126WP_001905700.1DUF645 family protein-
ASZ87_RS17810593397..593792+396WP_001000867.1hypothetical protein-
ASZ87_RS17815593931..594209-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
ASZ87_RS17820594206..594490-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ87_RS17825594684..595199+516WP_000343779.1GNAT family N-acetyltransferase-
ASZ87_RS17830595383..595796+414WP_000049420.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669
flankIS/Tn--589231..589668437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58321 WP_001114075.1 NZ_CP013310:591938-592207 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58321 NZ_CP013310:591938-592207 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT58321 WP_099607150.1 NZ_CP013310:591803-591907 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT58321 NZ_CP013310:591803-591907 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References