125040

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 916240..916778 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag FDZ90_RS18830 Protein ID WP_000802136.1
Coordinates 916240..916539 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag FDZ90_RS18835 Protein ID WP_001107719.1
Coordinates 916536..916778 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ90_RS18785 911986..912114 + 129 WP_071908338.1 general secretion pathway protein GspI -
FDZ90_RS18790 912175..912357 + 183 WP_000923182.1 DUF645 family protein -
FDZ90_RS18795 912557..913030 + 474 WP_001161076.1 GrpB family protein -
FDZ90_RS18800 913027..913137 + 111 WP_071908312.1 DUF3265 domain-containing protein -
FDZ90_RS18805 913179..913805 + 627 WP_000365424.1 LysE family translocator -
FDZ90_RS18810 913928..914626 + 699 WP_001890502.1 hypothetical protein -
FDZ90_RS18815 914630..914746 + 117 WP_071908339.1 DUF3265 domain-containing protein -
FDZ90_RS18820 915324..915503 + 180 WP_001883058.1 DUF645 family protein -
FDZ90_RS18825 915717..916112 + 396 WP_000870857.1 DUF3465 domain-containing protein -
FDZ90_RS18830 916240..916539 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDZ90_RS18835 916536..916778 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FDZ90_RS18840 917007..917585 + 579 WP_000110120.1 hypothetical protein -
FDZ90_RS18845 917589..917699 + 111 WP_071908313.1 DUF3265 domain-containing protein -
FDZ90_RS18850 918123..918806 + 684 WP_000877436.1 hypothetical protein -
FDZ90_RS18855 919020..919286 + 267 WP_000937852.1 hypothetical protein -
FDZ90_RS18860 919441..920040 + 600 WP_000429495.1 hypothetical protein -
FDZ90_RS18865 920321..921256 + 936 WP_000051985.1 restriction endonuclease -
FDZ90_RS18870 921222..921362 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 882589..977840 95251
inside Integron catB9 - 887669..977464 89795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T125040 WP_000802136.1 NZ_CP040173:c916539-916240 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T125040 NZ_CP040173:c916539-916240 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT125040 WP_001107719.1 NZ_CP040173:c916778-916536 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT125040 NZ_CP040173:c916778-916536 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References