Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 916240..916778 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag FDZ90_RS18830 Protein ID WP_000802136.1
Coordinates 916240..916539 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag FDZ90_RS18835 Protein ID WP_001107719.1
Coordinates 916536..916778 (-) Length 81 a.a.

Genomic Context

FDZ90_RS18785FDZ90_RS18790FDZ90_RS18795FDZ90_RS18800FDZ90_RS18805FDZ90_RS18810FDZ90_RS18815FDZ90_RS18820FDZ90_RS18825FDZ90_RS18840FDZ90_RS18845FDZ90_RS18850FDZ90_RS18855FDZ90_RS18860FDZ90_RS18865FDZ90_RS18870FDZ90_RS18830FDZ90_RS18835
Location: 911986..912114 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 912175..912357 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 912557..913030 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 913027..913137 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 913179..913805 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 913928..914626 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 914630..914746 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 915324..915503 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 915717..916112 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 917007..917585 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 917589..917699 (111 bp)
Type: Others
Protein ID: WP_071908313.1
Location: 918123..918806 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 919020..919286 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 919441..920040 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 920321..921256 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 921222..921362 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 916240..916539 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 916536..916778 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FDZ90_RS18785911986..912114+129WP_071908338.1general secretion pathway protein GspI-
FDZ90_RS18790912175..912357+183WP_000923182.1DUF645 family protein-
FDZ90_RS18795912557..913030+474WP_001161076.1GrpB family protein-
FDZ90_RS18800913027..913137+111WP_071908312.1DUF3265 domain-containing protein-
FDZ90_RS18805913179..913805+627WP_000365424.1LysE family translocator-
FDZ90_RS18810913928..914626+699WP_001890502.1hypothetical protein-
FDZ90_RS18815914630..914746+117WP_071908339.1DUF3265 domain-containing protein-
FDZ90_RS18820915324..915503+180WP_001883058.1DUF645 family protein-
FDZ90_RS18825915717..916112+396WP_000870857.1DUF3465 domain-containing protein-
FDZ90_RS18830916240..916539-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FDZ90_RS18835916536..916778-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
FDZ90_RS18840917007..917585+579WP_000110120.1hypothetical protein-
FDZ90_RS18845917589..917699+111WP_071908313.1DUF3265 domain-containing protein-
FDZ90_RS18850918123..918806+684WP_000877436.1hypothetical protein-
FDZ90_RS18855919020..919286+267WP_000937852.1hypothetical protein-
FDZ90_RS18860919441..920040+600WP_000429495.1hypothetical protein-
FDZ90_RS18865920321..921256+936WP_000051985.1restriction endonuclease-
FDZ90_RS18870921222..921362+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-882589..97784095251
insideIntegroncatB9-887669..97746489795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T125040 WP_000802136.1 NZ_CP040173:c916539-916240 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T125040 NZ_CP040173:c916539-916240 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT125040 WP_001107719.1 NZ_CP040173:c916778-916536 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT125040 NZ_CP040173:c916778-916536 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References