145398

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365274..365852 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GQX72_RS15605 Protein ID WP_001180243.1
Coordinates 365274..365591 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GQX72_RS15610 Protein ID WP_000557292.1
Coordinates 365610..365852 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS15560 360465..360860 + 396 WP_000046952.1 hypothetical protein -
GQX72_RS15565 361163..361344 + 182 Protein_347 DUF645 family protein -
GQX72_RS19030 361521..361916 + 396 WP_000046952.1 hypothetical protein -
GQX72_RS15570 362060..362596 + 537 WP_000644491.1 nucleotidyltransferase family protein -
GQX72_RS15575 362893..363072 + 180 WP_001883039.1 DUF645 family protein -
GQX72_RS15580 363268..363693 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
GQX72_RS15585 363842..364189 + 348 WP_000933409.1 hypothetical protein -
GQX72_RS15595 364336..364629 + 294 WP_125460920.1 hypothetical protein -
GQX72_RS19035 364985..365080 + 96 WP_001907607.1 DUF645 family protein -
GQX72_RS15605 365274..365591 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQX72_RS15610 365610..365852 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GQX72_RS15615 366094..366603 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
GQX72_RS15620 366660..367313 + 654 WP_000226874.1 hypothetical protein -
GQX72_RS15625 367623..367841 + 219 WP_001917086.1 DUF3709 domain-containing protein -
GQX72_RS15630 368244..368477 + 234 WP_032482776.1 DUF3709 domain-containing protein -
GQX72_RS15635 368902..369082 + 181 Protein_361 DUF645 family protein -
GQX72_RS15640 369349..369636 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
GQX72_RS15645 369647..369964 + 318 WP_001232701.1 HigA family addiction module antidote protein -
GQX72_RS19040 369961..370071 + 111 WP_134814058.1 DUF3265 domain-containing protein -
GQX72_RS15655 370248..370373 + 126 WP_001944767.1 DUF645 family protein -
GQX72_RS15660 370389..370427 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 311040..410783 99743
- inside Genomic island catB9 - 305960..411159 105199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145398 WP_001180243.1 NZ_CP047060:c365591-365274 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145398 NZ_CP062376:20493-20669 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145398 WP_000557292.1 NZ_CP047060:c365852-365610 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145398 NZ_CP062376:c20831-20657 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References