Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 431040..431824 Replicon chromosome
Accession NZ_LT906615
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag FY484_RS16530 Protein ID WP_001114075.1
Coordinates 431040..431309 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag FY484_RS16535 Protein ID WP_000921691.1
Coordinates 431303..431824 (+) Length 174 a.a.

Genomic Context

FY484_RS16490FY484_RS16495FY484_RS16500FY484_RS16505FY484_RS16510FY484_RS16515FY484_RS16520FY484_RS16525FY484_RS16530FY484_RS16535FY484_RS16540FY484_RS16550FY484_RS16565FY484_RS16575FY484_RS16590FY484_RS16555FY484_RS16560
Location: 426406..427323 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427480..427869 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428005..428214 (210 bp)
Type: Others
Protein ID: Protein_466
Location: 428333..428770 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 428834..429052 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429227..430099 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430249..430848 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 430905..431009 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 431040..431309 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 431303..431824 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 432123..432248 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 432499..432894 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 433786..434301 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 434485..434898 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 435453..436630 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 433033..433311 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 433308..433592 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FY484_RS16490426406..427323+918WP_000186333.1alpha/beta hydrolase-
FY484_RS16495427480..427869+390WP_001081302.1hypothetical protein-
FY484_RS16500428005..428214+210Protein_466GNAT family N-acetyltransferase-
FY484_RS16505428333..428770+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
FY484_RS16510428834..429052+219WP_071908318.1GNAT family N-acetyltransferase-
FY484_RS16515429227..430099+873WP_000254716.1DUF3800 domain-containing protein-
FY484_RS16520430249..430848+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
FY484_RS16525430905..431009+105WP_099607150.1acetyltransferase-
FY484_RS16530431040..431309+270WP_001114075.1DUF4160 domain-containing proteinToxin
FY484_RS16535431303..431824+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
FY484_RS16540432123..432248+126WP_001905700.1DUF645 family protein-
FY484_RS16550432499..432894+396WP_001000867.1hypothetical protein-
FY484_RS16555433033..433311-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
FY484_RS16560433308..433592-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
FY484_RS16565433786..434301+516WP_000343779.1GNAT family N-acetyltransferase-
FY484_RS16575434485..434898+414WP_000049420.1VOC family protein-
FY484_RS16590435453..436630+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639
flankIS/Tn--428333..428770437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T293808 WP_001114075.1 NZ_LT906615:431040-431309 [Vibrio cholerae O1 biovar El Tor str. N16961]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT293808 WP_000921691.1 NZ_LT906615:431303-431824 [Vibrio cholerae O1 biovar El Tor str. N16961]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References