145832

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 399694..400222 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GTF73_RS15875 Protein ID WP_000221352.1
Coordinates 399694..399984 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GTF73_RS15880 Protein ID WP_000213183.1
Coordinates 399974..400222 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS15840 395251..395455 + 205 Protein_411 DUF645 family protein -
GTF73_RS15845 395643..396647 + 1005 WP_000964925.1 LD-carboxypeptidase -
GTF73_RS15850 396800..397246 + 447 WP_000128977.1 hypothetical protein -
GTF73_RS15855 397366..398295 + 930 WP_000335802.1 hypothetical protein -
GTF73_RS15860 398292..398402 + 111 WP_071917832.1 DUF3265 domain-containing protein -
GTF73_RS15865 398430..398906 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
GTF73_RS15870 399043..399558 + 516 WP_001201528.1 lipocalin family protein -
GTF73_RS15875 399694..399984 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF73_RS15880 399974..400222 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF73_RS15885 400793..401446 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
GTF73_RS15890 401718..402143 + 426 WP_000415748.1 hypothetical protein -
GTF73_RS15895 402351..402746 + 396 WP_000649527.1 DUF3465 domain-containing protein -
GTF73_RS15900 402897..403427 + 531 WP_000415563.1 hypothetical protein -
GTF73_RS15905 403565..404065 + 501 WP_000789723.1 hypothetical protein -
GTF73_RS15910 404221..404619 + 399 WP_001882293.1 hypothetical protein -
GTF73_RS15915 404719..405183 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T145832 WP_000221352.1 NZ_CP047298:c399984-399694 [Vibrio cholerae O1 biovar El Tor]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T145832 NZ_CP062702:360703-360978 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT145832 WP_000213183.1 NZ_CP047298:c400222-399974 [Vibrio cholerae O1 biovar El Tor]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT145832 NZ_CP062702:360975-361334 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References