199007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 385040..385611 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag KAF59_RS15805 Protein ID WP_000351248.1
Coordinates 385210..385611 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag KAF59_RS18905 Protein ID WP_001080654.1
Coordinates 385040..385210 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS15750 (KAF59_15750) 380235..380349 + 115 Protein_395 acetyltransferase -
KAF59_RS15755 (KAF59_15755) 380358..380579 + 222 WP_032468461.1 DUF1289 domain-containing protein -
KAF59_RS15760 (KAF59_15760) 380745..380858 + 114 WP_001889158.1 hypothetical protein -
KAF59_RS15765 (KAF59_15765) 380807..381034 + 228 WP_001894457.1 DUF1289 domain-containing protein -
KAF59_RS15770 (KAF59_15770) 381375..381707 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAF59_RS15775 (KAF59_15775) 381694..382008 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
KAF59_RS15780 (KAF59_15780) 382145..382579 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
KAF59_RS15785 (KAF59_15785) 382747..382902 + 156 WP_000751734.1 hypothetical protein -
KAF59_RS15790 (KAF59_15790) 383027..384007 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
KAF59_RS15795 (KAF59_15795) 384075..384381 + 307 Protein_404 CatB-related O-acetyltransferase -
KAF59_RS18900 384518..384916 + 399 Protein_405 GNAT family N-acetyltransferase -
KAF59_RS18905 385040..385210 + 171 WP_001080654.1 hypothetical protein Antitoxin
KAF59_RS15805 (KAF59_15805) 385210..385611 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KAF59_RS15810 (KAF59_15810) 385614..385724 + 111 WP_082798255.1 DUF3265 domain-containing protein -
KAF59_RS15815 (KAF59_15815) 385799..386212 + 414 WP_000049417.1 VOC family protein -
KAF59_RS15820 (KAF59_15820) 386426..386677 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KAF59_RS15825 (KAF59_15825) 386667..386954 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAF59_RS15830 (KAF59_15830) 387082..387537 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
KAF59_RS18910 387594..387716 + 123 Protein_413 acetyltransferase -
KAF59_RS15835 (KAF59_15835) 387887..388011 + 125 Protein_414 DUF645 family protein -
KAF59_RS18915 388128..388196 + 69 Protein_415 acetyltransferase -
KAF59_RS15840 (KAF59_15840) 388213..388710 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
KAF59_RS15845 (KAF59_15845) 388707..388979 - 273 WP_000246253.1 DUF1778 domain-containing protein -
KAF59_RS18920 389131..389193 + 63 Protein_418 acetyltransferase -
KAF59_RS15850 (KAF59_15850) 389210..389878 + 669 WP_000043871.1 hypothetical protein -
KAF59_RS15855 (KAF59_15855) 390030..390317 + 288 WP_000426470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805
flank IS/Tn - - 383027..384007 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T199007 WP_000351248.1 NZ_CP072850:385210-385611 [Vibrio cholerae MO10]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T199007 NZ_CP097097:69570-69950 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT199007 WP_001080654.1 NZ_CP072850:385040-385210 [Vibrio cholerae MO10]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT199007 NZ_CP097097:69349-69570 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References