125052

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 975112..975671 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag FDZ90_RS19355 Protein ID WP_000578476.1
Coordinates 975112..975390 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag FDZ90_RS19360 Protein ID WP_000381183.1
Coordinates 975387..975671 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ90_RS19310 970413..970850 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
FDZ90_RS19315 970913..971131 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
FDZ90_RS19320 971306..972178 + 873 WP_000254716.1 DUF3800 domain-containing protein -
FDZ90_RS19325 972328..972927 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
FDZ90_RS19330 972984..973088 + 105 WP_099607150.1 acetyltransferase -
FDZ90_RS19335 973119..973388 + 270 WP_001114075.1 DUF4160 domain-containing protein -
FDZ90_RS19340 973382..973903 + 522 WP_000921691.1 DUF2442 domain-containing protein -
FDZ90_RS19345 974202..974327 + 126 WP_001905700.1 DUF645 family protein -
FDZ90_RS19350 974578..974973 + 396 WP_001000867.1 hypothetical protein -
FDZ90_RS19355 975112..975390 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FDZ90_RS19360 975387..975671 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FDZ90_RS19365 975865..976380 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
FDZ90_RS19370 976564..976977 + 414 WP_000049420.1 VOC family protein -
FDZ90_RS19375 977532..978709 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 882589..977840 95251
inside Integron catB9 - 887669..977464 89795
flank IS/Tn - - 970413..970850 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T125052 WP_000578476.1 NZ_CP040173:c975390-975112 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T125052 NZ_CP040173:c975390-975112 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT125052 WP_000381183.1 NZ_CP040173:c975671-975387 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT125052 NZ_CP040173:c975671-975387 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References