Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 975112..975671 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag FDZ90_RS19355 Protein ID WP_000578476.1
Coordinates 975112..975390 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag FDZ90_RS19360 Protein ID WP_000381183.1
Coordinates 975387..975671 (-) Length 95 a.a.

Genomic Context

FDZ90_RS19310FDZ90_RS19315FDZ90_RS19320FDZ90_RS19325FDZ90_RS19330FDZ90_RS19335FDZ90_RS19340FDZ90_RS19345FDZ90_RS19350FDZ90_RS19365FDZ90_RS19370FDZ90_RS19375FDZ90_RS19355FDZ90_RS19360
Location: 970413..970850 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 970913..971131 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 971306..972178 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 972328..972927 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 972984..973088 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 973119..973388 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 973382..973903 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 974202..974327 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 974578..974973 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 975865..976380 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 976564..976977 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 977532..978709 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 975112..975390 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 975387..975671 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FDZ90_RS19310970413..970850+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
FDZ90_RS19315970913..971131+219WP_071908318.1GNAT family N-acetyltransferase-
FDZ90_RS19320971306..972178+873WP_000254716.1DUF3800 domain-containing protein-
FDZ90_RS19325972328..972927+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
FDZ90_RS19330972984..973088+105WP_099607150.1acetyltransferase-
FDZ90_RS19335973119..973388+270WP_001114075.1DUF4160 domain-containing protein-
FDZ90_RS19340973382..973903+522WP_000921691.1DUF2442 domain-containing protein-
FDZ90_RS19345974202..974327+126WP_001905700.1DUF645 family protein-
FDZ90_RS19350974578..974973+396WP_001000867.1hypothetical protein-
FDZ90_RS19355975112..975390-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
FDZ90_RS19360975387..975671-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
FDZ90_RS19365975865..976380+516WP_000343779.1GNAT family N-acetyltransferase-
FDZ90_RS19370976564..976977+414WP_000049420.1VOC family protein-
FDZ90_RS19375977532..978709+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-882589..97784095251
insideIntegroncatB9-887669..97746489795
flankIS/Tn--970413..970850437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T125052 WP_000578476.1 NZ_CP040173:c975390-975112 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T125052 NZ_CP040173:c975390-975112 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT125052 WP_000381183.1 NZ_CP040173:c975671-975387 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT125052 NZ_CP040173:c975671-975387 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References