Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 366339..366917 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF74_RS15570 Protein ID WP_001180243.1
Coordinates 366339..366656 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF74_RS15575 Protein ID WP_000557292.1
Coordinates 366675..366917 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF74_RS15525 361569..361925 + 357 WP_001094969.1 hypothetical protein -
GTF74_RS15530 362228..362409 + 182 Protein_352 DUF645 family protein -
GTF74_RS15535 362586..362981 + 396 WP_000046953.1 hypothetical protein -
GTF74_RS15540 363125..363661 + 537 WP_000644491.1 nucleotidyltransferase family protein -
GTF74_RS15545 363958..364137 + 180 WP_001883039.1 DUF645 family protein -
GTF74_RS15550 364333..364758 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
GTF74_RS15555 364907..365254 + 348 WP_000933409.1 hypothetical protein -
GTF74_RS15560 365401..365694 + 294 WP_125460920.1 hypothetical protein -
GTF74_RS15565 366050..366145 + 96 WP_001907607.1 DUF645 family protein -
GTF74_RS15570 366339..366656 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF74_RS15575 366675..366917 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF74_RS15580 367159..367668 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
GTF74_RS15585 367725..368378 + 654 WP_000226874.1 hypothetical protein -
GTF74_RS15590 368688..368906 + 219 WP_001917086.1 DUF3709 domain-containing protein -
GTF74_RS15595 369309..369542 + 234 WP_032482776.1 DUF3709 domain-containing protein -
GTF74_RS15600 369967..370147 + 181 Protein_366 DUF645 family protein -
GTF74_RS15605 370414..370701 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF74_RS15610 370712..371029 + 318 WP_001232701.1 HigA family addiction module antidote protein -
GTF74_RS15615 371026..371136 + 111 WP_134814058.1 DUF3265 domain-containing protein -
GTF74_RS15620 371313..371438 + 126 WP_001944767.1 DUF645 family protein -
GTF74_RS15625 371454..371492 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 307032..436751 129719
inside Integron - - 312112..436375 124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145889 WP_001180243.1 NZ_CP047304:c366656-366339 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145889 NZ_CP062706:51521-51826 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145889 WP_000557292.1 NZ_CP047304:c366917-366675 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145889 NZ_CP062706:51301-51519 [Escherichia coli O157:H7]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References